Max Roser, Esteban Ortiz-Ospina, Hannah Ritchie. Roser-Life-Expectancy-Our-World-in-Data-withIreland-20200929-1908. Our World Data. 2013;1–26.
Kontis V, Bennett JE, Mathers CD, Li G, Foreman K, Ezzati M. Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble. Lancet. 2017;389:1323–35.
Flatt T, Partridge L. Horizons in the evolution of aging. BMC Biol. 2018;16:93.
Seals DR, Justice JN, LaRocca TJ. Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol. 2016;594:2001–24.
Crimmins EM. Lifespan and healthspan: past, present, and promise. Gerontologist. 2015;55:901–11.
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet (London, England). 2018;392:1859–922.
Russo GL, Spagnuolo C, Russo M, Tedesco I, Moccia S, Cervellera C. Mechanisms of aging and potential role of selected polyphenols in extending healthspan. Biochem Pharmacol. England; 2020;173:113719.
Li Y, Schoufour J, Wang DD, Dhana K, Pan A, Liu X, et al. Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study. BMJ. 2020;368: l6669.
Abbott A. Ageing: growing old gracefully. Nature 2004. p. 116–8.
da Costa JP, Vitorino R, Silva GM, Vogel C, Duarte AC, Rocha-Santos T. A synopsis on aging-theories, mechanisms and future prospects. Ageing Res Rev. 2016;29:90–112.
Ferrucci L, Levine ME, Kuo P-L, Simonsick EM. Time and the metrics of aging. Circ Res. 2018;123:740–4.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The Hallmarks of Aging Europe PMC Funders Group. Cell. 2013;153:1194–217. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/pdf/emss-55354.pdf
Fasching CL. Telomere length measurement as a clinical biomarker of aging and disease. Crit Rev Clin Lab Sci. 2018;55:443–65.
Turner KJ, Vasu V, Griffin DK. Telomere biology and human phenotype. Cells. 2019;8.
Sanders JL, Newman AB. Telomere length in epidemiology: A biomarker of aging, age-related disease, both, or neither? Epidemiol Rev. 2013;35:112–31.
Oeseburg H, de Boer RA, van Gilst WH, van der Harst P. Telomere biology in healthy aging and disease. Pflugers Arch. 2010;459:259–68.
Lulkiewicz M, Bajsert J, Kopczynski P, Barczak W, Rubis B. Telomere length: how the length makes a difference. Mol Biol Rep. 2020;47:7181–8.
Wang Q, Zhan Y, Pedersen NL, Fang F, Hägg S. Telomere length and all-cause mortality: a meta-analysis. Ageing Res Rev. 2018;48:11–20.
Khan SS, Singer BD, Vaughan DE. Molecular and physiological manifestations and measurement of aging in humans. Aging Cell. 2017;16:624–33.
Razgonova MP, Zakharenko AM, Golokhvast KS, Thanasoula M, Sarandi E, Nikolouzakis K, et al. Telomerase and telomeres in aging theory and chronographic aging theory (review). Mol Med Rep. 2020;22:1679–94.
Rizvi S, Raza ST, Mahdi F. Telomere length variations in aging and age-related diseases. Curr Aging Sci. 2014;7:161–7.
Blackburn EH, Epel ES, Lin J. Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection. Science. 2015;350:1193–8.
Calado RT, Young NS. Telomere diseases. N Engl J Med. 2009;361:2353–65.
Cleal K, Norris K, Baird D. Telomere length dynamics and the evolution of cancer genome architecture. Int J Mol Sci. 2018;19.
Ridout KK, Khan M, Ridout SJ. Adverse childhood experiences run deep: toxic early life stress, telomeres, and mitochondrial DNA copy number, the biological markers of cumulative stress. Bioessays. United States; 2018;40:e1800077.
Ridout KK, Ridout SJ, Guille C, Mata DA, Akil H, Sen S. Physician-training stress and accelerated cellular aging. Biol Psychiatry. 2019;86:725–30.
Guzzardi MA, Iozzo P, Salonen M, Kajantie E, Eriksson JG. Rate of telomere shortening and metabolic and cardiovascular risk factors: a longitudinal study in the 1934–44 Helsinki Birth Cohort Study. Ann Med. 2015;47:499–505.
Aulinas A, Ramírez M-J, Barahona M-J, Valassi E, Resmini E, Mato E, et al. Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing’s syndrome. PLoS ONE. 2015;10: e0120185.
Kuo C-L, Pilling LC, Kuchel GA, Ferrucci L, Melzer D. Telomere length and aging-related outcomes in humans: a Mendelian randomization study in 261,000 older participants. Aging Cell. 2019;18: e13017.
Herrmann M, Pusceddu I, März W, Herrmann W. Telomere biology and age-related diseases. Clin Chem Lab Med. 2018;56:1210–22.
Balan E, Decottignies A, Deldicque L. Physical activity and nutrition: Two promising strategies for telomere maintenance? Nutrients. 2018;10.
Crous-Bou M, Molinuevo J-L, Sala-Vila A. Plant-rich dietary patterns, plant foods and nutrients, and telomere length. Adv Nutr. 2019;10:S296-303.
Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, et al. Obesity, cigarette smoking, and telomere length in women. Lancet (London, England). England; 2005;366:662–4.
Rebelo-Marques A, Lages ADS, Andrade R, Ribeiro CF, Mota-Pinto A, Carrilho F, et al. Aging hallmarks: the benefits of physical exercise. Front Endocrinol. 2018;9:1–15.
Daskalopoulou C, Stubbs B, Kralj C, Koukounari A, Prince M, Prina AM. Physical activity and healthy ageing: a systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev. 2017;38:6–17.
Harridge SDR, Lazarus NR. Physical activity, aging, and physiological function. Physiology. 2017.
Lemanne D, Cassileth B, Gubili J. The role of physical activity in cancer prevention, treatment, recovery, and survivorship. Oncology 2013;27:580–5.
Sampath Kumar A, Maiya AG, Shastry BA, Vaishali K, Ravishankar N, Hazari A, et al. Exercise and insulin resistance in type 2 diabetes mellitus: a systematic review and meta-analysis. Ann Phys Rehabil Med. 2019;62:98–103.
Ozemek C, Laddu DR, Lavie CJ, Claeys H, Kaminsky LA, Ross R, et al. An update on the role of cardiorespiratory fitness, structured exercise and lifestyle physical activity in preventing cardiovascular disease and health risk. Prog Cardiovasc Dis. 2018;61:484–90.
Denham J, O’Brien BJ, Charchar FJ. Telomere length maintenance and cardio-metabolic disease prevention through exercise training. Sports Med. 2016;46:1213–37.
Chakravarti D, LaBella KA, DePinho RA. Telomeres: history, health, and hallmarks of aging. Cell. 2021;184:306–22.
Semeraro MD, Smith C, Kaiser M, Levinger I, Duque G, Gruber HJ, et al. Physical activity, a modulator of aging through effects on telomere biology. Aging. 2020;12:13803–23.
Valente C, Andrade R, Alvarez L, Rebelo-Marques A, Stamatakis E, Espregueira-Mendes J. Effect of physical activity and exercise on telomere length: systematic review with meta-analysis. J Am Geriatr Soc. 2021;69:3285–300.
Aguiar SS, Sousa C V, Santos PA, Barbosa LP, Maciel LA, Coelho-Júnior HJ, et al. Master athletes have longer telomeres than age-matched non-athletes. A systematic review, meta-analysis and discussion of possible mechanisms. Exp Gerontol 2021;146:111212.
Song S, Lee E, Kim H. Does Exercise Affect Telomere length? A systematic review and meta-analysis of randomized controlled trials. Medicina. 2022;58.
Mundstock E, Zatti H, Louzada FM, Oliveira SG, Guma FTCR, Paris MM, et al. Effects of physical activity in telomere length: Systematic review and meta-analysis. Ageing Res Rev 2015;22:72–80. https://doi.org/10.1016/j.arr.2015.02.004
Borghini A, Giardini G, Tonacci A, Mastorci F, Mercuri A, Mrakic-Sposta S, et al. Chronic and acute effects of endurance training on telomere length. Mutagenesis. 2015;30:711–6.
Nickels M, Mastana S, Denniff M, Codd V, Akam E. Elite swimmers possess shorter telomeres than recreationally active controls. Gene. 2021;769.
Jantunen H, Wasenius NS, Guzzardi MA, Iozzo P, Kajantie E, Kautiainen H, et al. Physical activity and telomeres in old age: a longitudinal 10-year follow-up study. Gerontology. 2020;66:315–22.
Weischer M, Bojesen SE, Nordestgaard BG. Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart. PLOS Genet. 2014;10.
Arsenis NC, You T, Ogawa EF, Tinsley GM, Zuo L. Physical activity and telomere length: impact of aging and potential mechanisms of action. Oncotarget. 2017;8:45008–19.
Friedenreich CM, Wang Q, Ting NS, Brenner DR, Conroy SM, McIntyre JB, et al. Effect of a 12-month exercise intervention on leukocyte telomere length: results from the ALPHA Trial. Cancer Epidemiol. 2018;56:67–74.
Mason C, Risques R-A, Xiao L, Duggan CR, Imayama I, Campbell KL, et al. Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women. Obesity. 2013;21:E549–54.
Bassett DRJ, Howley ET. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exerc. 2000;32:70–84.
Puterman E, Weiss J, Lin J, Schilf S, Slusher AL, Johansen KL, et al. Aerobic exercise lengthens telomeres and reduces stress in family caregivers: a randomized controlled trial—Curt Richter Award Paper 2018. Psychoneuroendocrinology. 2018;98:245–52.
Brandao CFC, Nonino CB, de Carvalho FG, Nicoletti CF, Noronha NY, San Martin R, et al. The effects of short-term combined exercise training on telomere length in obese women: a prospective, interventional study. Sport Med—Open. Sports Medicine—Open; 2020;6.
Werner CM, Hecksteden A, Morsch A, Zundler J, Wegmann M, Kratzsch J, et al. Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study. Eur Heart J. 2019;40:34–46.
Hooshmand-Moghadam B, Eskandari M, Golestani F, Rezae S, Mahmoudi N, Gaeini AA. The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men. Exp Gerontol. England; 2020;141:111090.
Denham J, O’Brien BJ, Prestes PR, Brown NJ, Charchar FJ. Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres. J Appl Physiol. 2016;120:148–58.
Colon M, Hodgson A, Donlon E, Murphy JEJ. Effects of competitive triathlon training on telomere length. J Aging Phys Act. 2019;27:510–4.
Aguiar SS, Rosa TS, Sousa C V, Santos PA, Barbosa LP, Deus LA, et al. Influence of body fat on oxidative stress and telomere length of master athletes. J Strength Cond Res. 2019.
Hagman M, Werner C, Kamp K, Fristrup B, Hornstrup T, Meyer T, et al. Reduced telomere shortening in lifelong trained male football players compared to age-matched inactive controls. Prog Cardiovasc Dis. 2020;63:738–49.
Denham J, Nelson CP, O’Brien BJ, Nankervis SA, Denniff M, Harvey JT, et al. Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors. PLoS ONE. 2013;8: e69377.
Jylhävä J, Pedersen NL, Hägg S. Biological age predictors. EBioMedicine. 2017;21:29–36.
Stenbäck V, Mutt SJ, Leppäluoto J, Gagnon DD, Mäkelä KA, Jokelainen J, et al. Association of physical activity with telomere length among elderly adults—The Oulu Cohort 1945. Front Physiol. 2019;10:444.
Pusceddu I, Kleber M, Delgado G, Herrmann W, März W, Herrmann M. Telomere length and mortality in the Ludwigshafen Risk and Cardiovascular Health study. PLoS ONE. 2018;13: e0198373.
Mangge H, Renner W, Almer G, Gruber H-J, Zelzer S, Moeller R, et al. Subcutaneous adipose tissue distribution and telomere length. Clin Chem Lab Med. 2019;57:1358–63.
Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, et al. Automated assay of telomere length measurement and informatics for 100,000 subjects in the genetic epidemiology research on adult health and aging (GERA) cohort. Genetics. 2015;200:1061–72.
Lin J, Smith DL, Esteves K, Drury S. Telomere length measurement by qPCR—summary of critical factors and recommendations for assay design. Psychoneuroendocrinology. 2019;99:271–8.
Saßenroth D, Meyer A, Salewsky B, Kroh M, Norman K, Steinhagen-Thiessen E, et al. Sports and exercise at different ages and leukocyte telomere length in later life—data from the berlin aging Study II (BASE-II). PLoS ONE. 2015;10: e0142131.
Latifovic L, Peacock SD, Massey TE, King WD. The Influence of Alcohol Consumption, Cigarette Smoking, and Physical Activity on Leukocyte Telomere Length. CANCER Epidemiol BIOMARKERS \& Prev. 2016;25:374–80.
Dankel SJ, Loenneke JP, Loprinzi PD. The impact of overweight/obesity duration and physical activity on telomere length: An application of the WATCH paradigm. Obes Res \& Clin Pract. 2017;11:247–52.
Edwards MK, Loprinzi PD. Sedentary behavior, physical activity and cardiorespiratory fitness on leukocyte telomere length. Heal Promot Perspect. 2017;7:22–7.
Shadyab AH, LaMonte MJ, Kooperberg C, Reiner AP, Carty CL, Manini TM, et al. Association of accelerometer-measured physical activity with leukocyte telomere length among older women. J Gerontol Ser A-Biol Sci Med Sci. 2017;72:1532–7.
Fretts AM, Mete M, Howard BV, Best LG, Siscovick DS, Eilat-Adar S, et al. Physical activity and telomere length in American Indians: the Strong Heart Study. Eur J Epidemiol. 2018;33:497–500.
Du M, Prescott J, Kraft P, Han J, Giovannucci E, Hankinson SE, et al. Physical activity, sedentary behavior, and leukocyte telomere length in women. Am J Epidemiol. 2012;175:414–22.
Savela S, Saijonmaa O, Strandberg TE, Koistinen P, Strandberg AY, Tilvis RS, et al. Physical activity in midlife and telomere length measured in old age. Exp Gerontol. 2013;48:81–4.
Åström MJ, von Bonsdorff MB, Perälä M-M, Salonen MK, Rantanen T, Kajantie E, et al. Telomere length and physical performance among older people-The Helsinki Birth Cohort Study. Mech Ageing Dev. Ireland; 2019;183:111145.
Shadyab AH, LaMonte MJ, Kooperberg C, Reiner AP, Carty CL, Manini TM, et al. Leisure-time physical activity and leukocyte telomere length among older women. Exp Gerontol. 2017;95:141–7.
Loprinzi PD, Loenneke JP, Blackburn EH. Movement-based behaviors and leukocyte telomere length among US adults. Med Sci Sports Exerc. 2015;47:2347–52.
Sillanpaa E, Tormakangas T, Rantanen T, Kaprio J, Sipila S. Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up? Age (Omaha). 2016;38.
Loprinzi PA, Sng E. Mode-specific physical activity and leukocyte telomere length among US adults: implications of running on cellular aging. Prev Med. 2016;85:17–9.
Pedisic Z, Shrestha N, Kovalchik S, Stamatakis E, Liangruenrom N, Grgic J, et al. Is running associated with a lower risk of all-cause, cardiovascular and cancer mortality, and is the more the better? A systematic review and meta-analysis. Br J Sports Med. 2020;54:898–905.
Tamura Y, Takubo K, Aida J, Araki A, Ito H. Telomere attrition and diabetes mellitus. Geriatr Gerontol Int. Japan; 2016;16 Suppl 1:66–74.
Green DJ, Hopman MTE, Padilla J, Laughlin MH, Thijssen DHJ. Vascular adaptation to exercise in humans: role of hemodynamic stimuli. Physiol Rev. 2017;97:495–528.
Werner C, Fürster T, Widmann T, Pöss J, Roggia C, Hanhoun M, et al. Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation. 2009;120:2438–47.
Tosevska A, Franzke B, Hofmann M, Vierheilig I, Schober-Halper B, Oesen S, et al. Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial. Sci Rep. 2016;6:38084.
Chen L, Shivappa N, Dong X, Ming J, Zhao Q, Xu H, et al. Association between appendicular skeletal muscle index and leukocyte telomere length in adults: A study from National Health and Nutrition Examination Survey (NHANES) 1999–2002. Clin Nutr. England; 2020.
Saretzki G. Telomeres, telomerase and ageing. Subcell Biochem. 2018;90:221–308.
Xin M, Jin X, Cui X, Jin C, Piao L, Wan Y, et al. Dipeptidyl peptidase-4 inhibition prevents vascular aging in mice under chronic stress: modulation of oxidative stress and inflammation. Chem Biol Interact. 2019;314:108842.
Wirtz PH, von Känel R. Psychological Stress, Inflammation, and coronary heart disease. Curr Cardiol Rep. 2017;19:111.
Rohleder N. Stress and inflammation—the need to address the gap in the transition between acute and chronic stress effects. Psychoneuroendocrinology. 2019;105:164–71.
Gioscia-Ryan RA, Clayton ZS, Zigler MC, Richey JJ, Cuevas LM, Rossman MJ, et al. Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice. J Physiol. 2021;599:911–25.
Seals DR, Nagy EE, Moreau KL. Aerobic exercise training and vascular function with ageing in healthy men and women. J Physiol. 2019;597:4901–14.
Rosa TS, Passos Neves RV, Deus LA, Sousa CV, Aguiar S da S, de Souza MK, et al. Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes. Nitric Oxide-Biol Chem. 2020;102:42–51.
Bastos MF, Matias M de ST, Alonso ACAC, Silva LCR, de Araújo AL, Silva PR, et al. Moderate levels of physical fitness maintain telomere length in non-senescent T CD8(+) cells of aged men. Clinics. 2020;75:e1628.
Eigendorf J, Melk A, Haufe S, Boethig D, Berliner D, Kerling A, et al. Effects of personalized endurance training on cellular age and vascular function in middle-aged sedentary women. Eur. J. Prev. Cardiol. 2019. p. 1903–6.
Gagnon DD, Dormanta S, Ritchie S, Mutt SJ, Stenback V, Walkowiak J, et al. Multi-day prolonged low- to moderate-intensity endurance exercise mimics training improvements in metabolic and oxidative profiles without concurrent chromosomal changes in healthy adults. Front Physiol. 2019;10.
Ogawa EF, Leveille SG, Wright JA, Shi L, Camhi SM, You T. Physical activity domains/recommendations and leukocyte telomere length in US adults. Med Sci Sports Exerc. 2017;49:1371–8.
Muniesa CA, Verde Z, Diaz-Urena G, Santiago C, Gutierrez F, Diaz E, et al. Telomere length in elite athletes. Int J Sports Physiol Perform. 2017;12:994–6.
Mrakic-Sposta S, Gussoni M, Moretti S, Pratali L, Giardini G, Tacchini P, et al. Effects of mountain ultra-marathon running on ROS production and oxidative damage by micro-invasive analytic techniques. PLoS ONE. 2015;10: e0141780.
Skenderi KP, Tsironi M, Lazaropoulou C, Anastasiou CA, Matalas A-L, Kanavaki I, et al. Changes in free radical generation and antioxidant capacity during ultramarathon foot race. Eur J Clin Investig. 2008;38:159–65.
Tanimura Y, Shimizu K, Tanabe K, Kono I, Ajisaka R. Effects of three consecutive days exercise on lymphocyte DNA damage in young men. Eur J Appl Physiol. 2010;110:307–14.
Tryfidou DV, McClean C, Nikolaidis MG, Davison GW. DNA damage following acute aerobic exercise: a systematic review and meta-analysis. Sports Med. 2020;50:103–27.
Guan J-Z, Guan W-P, Maeda T, Makino N. Effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer’s disease. Gerontology. 2012;58:62–9.
Matthews C, Gorenne I, Scott S, Figg N, Kirkpatrick P, Ritchie A, et al. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress. Circ Res. 2006;99:156–64.
Laye MJ, Solomon TPJ, Karstoft K, Pedersen KK, Nielsen SD, Pedersen BK. Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle following an ultra-long-distance running event. J Appl Physiol. 2012;112:773–81.
Kadi F, Ponsot E. The biology of satellite cells and telomeres in human skeletal muscle: effects of aging and physical activity. Scand J Med Sci Sports. 2010;20:39–48.
de Rezende LFM, Rey-López JP, Matsudo VKR, do Carmo Luiz O. Sedentary behavior and health outcomes among older adults: a systematic review. BMC Public Health. 2014;14:333.
Carter S, Hartman Y, Holder S, Thijssen DH, Hopkins ND. Sedentary behavior and cardiovascular disease risk: mediating mechanisms. Exerc Sport Sci Rev. 2017;45:80–6.
Patterson R, McNamara E, Tainio M, de Sá TH, Smith AD, Sharp SJ, et al. Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis. Eur J Epidemiol. 2018;33:811–29.
Lavie CJ, Ozemek C, Carbone S, Katzmarzyk PT, Blair SN. Sedentary behavior, exercise, and cardiovascular health. Circ Res. 2019;124:799–815.
Dunstan DW, Howard B, Healy GN, Owen N. Too much sitting–a health hazard. Diabetes Res Clin Pract. 2012;97:368–76.
Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS, et al. Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis. Ann Intern Med. 2015;162:123–32.
Li R, Xia J, Zhang XI, Gathirua-Mwangi WG, Guo J, Li Y, et al. Associations of muscle mass and strength with all-cause mortality among US older adults. Med Sci Sports Exerc. 2018;50:458–67.
Lessiani G, Santilli F, Boccatonda A, Iodice P, Liani R, Tripaldi R, et al. Arterial stiffness and sedentary lifestyle: role of oxidative stress. Vascul Pharmacol. 2016;79:1–5.
Healy GN, Matthews CE, Dunstan DW, Winkler EAH, Owen N. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003–06. Eur Heart J. 2011;32:590–7.
Sjögren P, Fisher R, Kallings L, Svenson U, Roos G, Hellénius M-L. Stand up for health–avoiding sedentary behaviour might lengthen your telomeres: secondary outcomes from a physical activity RCT in older people. Br J Sports Med. 2014;48:1407–9.
Johansson JK, Kujala UM, Sarna S, Karanko H, Puukka PJ, Jula AM. Cardiovascular health in former elite male athletes. Scand J Med Sci Sports. 2016;26:535–43.
Laine MK, Kujala UM, Eriksson JG, Wasenius NS, Kaprio J, Bäckmand HM, et al. Former male elite athletes and risk of hypertension in later life. J Hypertens. 2015;33:1549–54.
Laine MK, Eriksson JG, Kujala UM, Kaprio J, Loo B-M, Sundvall J, et al. Former male elite athletes have better metabolic health in late life than their controls. Scand J Med Sci Sports. 2016;26:284–90.
Sanchis-Gomar F, Olaso-Gonzalez G, Corella D, Gomez-Cabrera MC, Vina J. Increased average longevity among the “Tour de France” cyclists. Int J Sports Med. 2011;32:644–7.
Hernando B, Gil-Barrachina M, Tomas-Bort E, Martinez-Navarro I, Collado-Boira E, Hernando C. The effect of long-term ultra-endurance exercise and SOD2 genotype on telomere shortening with age. J Appl Physiol. 2020;129:873–9.
Laine MK, Eriksson JG, Kujala UM, Raj R, Kaprio J, Backmand HM, et al. Effect of intensive exercise in early adult life on telomere length in later life in men. J Sport Sci Med. 2015;14:239–45.
LaRocca TJ, Seals DR, Pierce GL. Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mech Ageing Dev. 2010;131:165–7.
Crocco P, De Rango F, Dato S, Rose G, Passarino G. Telomere length as a function of age at population level parallels human survival curves. Aging. 2021;13:204–18.
Cluckey TG, Nieto NC, Rodoni BM, Traustadóttir T. Preliminary evidence that age and sex affect exercise-induced hTERT expression. Exp Gerontol. 2017;96:7–11.
Itoh H, Kaneko H, Kiriyama H, Kamon T, Mizuno Y, Morita H, et al. Association between changes in body weight and fat weight in middle age general population. Int Heart J. 2020;61:15–20.
Verkouter I, Noordam R, Loh NY, van Dijk KW, Zock PL, Mook-Kanamori DO, et al. The relation between adult weight gain, adipocyte volume, and the metabolic profile at middle age. J Clin Endocrinol Metab. 2021;106:e4438–47.
Willis LH, Slentz CA, Bateman LA, Shields AT, Piner LW, Bales CW, et al. Effects of aerobic and/or resistance training on body mass and fat mass in overweight or obese adults. J Appl Physiol. 2012;113:1831–7.
Diman A, Boros J, Poulain F, Rodriguez J, Purnelle M, Episkopou H, et al. Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription. Sci Adv. 2016;2.
Demanelis K, Jasmine F, Chen LS, Chernoff M, Tong L, Delgado D, et al. Determinants of telomere length across human tissues. Science. 2020;369.
Dlouha D, Maluskova J, Kralova Lesna I, Lanska V, Hubacek JA. Comparison of the relative telomere length measured in leukocytes and eleven different human tissues. Physiol Res. 2014;63:S343–50.
Denham J. Lack of association between PBMC telomere length and endurance exercise. J Appl Biomed. 2017;15:9–13.
Ludlow AT, Witkowski S, Marshall MR, Wang J, Lima LCJ, Guth LM, et al. Chronic exercise modifies age-related telomere dynamics in a tissue-specific fashion. J Gerontol Ser A Biol Sci Med Sci. 2012;67:911–26.
Daniali L, Benetos A, Susser E, Kark JD, Labat C, Kimura M, et al. Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun. 2013;4:1597.
Ishikawa N, Nakamura K-I, Izumiyama-Shimomura N, Aida J, Matsuda Y, Arai T, et al. Changes of telomere status with aging: An update. Geriatr Gerontol Int. 2016;16 Suppl 1:30–42.
Decary S, Mouly V, Hamida CB, Sautet A, Barbet JP, Butler-Browne GS. Replicative potential and telomere length in human skeletal muscle: implications for satellite cell-mediated gene therapy. Hum Gene Ther. 1997;8:1429–38.
Magi F, Dimauro I, Margheritini F, Duranti G, Mercatelli N, Fantini C, et al. Telomere length is independently associated with age, oxidative biomarkers, and sport training in skeletal muscle of healthy adult males. Free Radic Res. 2018;52:639–47.
Hiam D, Smith C, Voisin S, Denham J, Yan X, Landen S, et al. Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan. Aging. 2020;12:359–69.
Lin J, Cheon J, Brown R, Coccia M, Puterman E, Aschbacher K, et al. Systematic and cell type-specific telomere length changes in subsets of lymphocytes. J Immunol Res. 2016;2016:5371050.
Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, et al. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods. 2010;352:71–80.
Martens UM, Brass V, Sedlacek L, Pantic M, Exner C, Guo Y, et al. Telomere maintenance in human B lymphocytes. Br J Haematol. 2002;119:810–8.
Svenson U, Nordfjall K, Baird D, Roger L, Osterman P, Hellenius M-L, et al. Blood cell telomere length is a dynamic feature. PLoS ONE. 2011;6.
Coluzzi E, Leone S, Sgura A. Oxidative Stress Induces Telomere dysfunction and senescence by replication fork arrest. Cells. 2019;8.
Kumar S, Dikshit M. Metabolic insight of neutrophils in health and disease. Front Immunol. 2019;10:2099.
Dröge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47–95.
Gomes MJ, Martinez PF, Pagan LU, Damatto RL, Cezar MDM, Lima ARR, et al. Skeletal muscle aging: influence of oxidative stress and physical exercise. Oncotarget. 2017;8:20428–40.
Sousa CV, Aguiar SS, Santos PA, Barbosa LP, Knechtle B, Nikolaidis PT, et al. Telomere length and redox balance in master endurance runners: the role of nitric oxide. Exp Gerontol. 2019;117:113–8.
Reichert S, Stier A. Does oxidative stress shorten telomeres in vivo? A review. Biol Lett. 2017;13.
Barnes RP, Fouquerel E, Opresko PL. The impact of oxidative DNA damage and stress on telomere homeostasis. Mech Ageing Dev. 2019;177:37–45.
Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021;22:283–98.
Marión RM, Montero JJ, López de Silanes I, Graña-Castro O, Martínez P, Schoeftner S, et al. TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2. Elife. 2019;8.
Tennen RI, Bua DJ, Wright WE, Chua KF. SIRT6 is required for maintenance of telomere position effect in human cells. Nat Commun. 2011;2:433.
Vinayagamurthy S, Ganguly A, Chowdhury S. Extra-telomeric impact of telomeres: emerging molecular connections in pluripotency or stemness. J Biol Chem. 2020;295:10245–54.
Kim W, Ludlow AT, Min J, Robin JD, Stadler G, Mender I, et al. Regulation of the human telomerase gene TERT by telomere position effect-over long distances (TPE-OLD): implications for aging and cancer. PLoS Biol. 2016;14: e2000016.
Rossiello F, Jurk D, Passos JF, d’Adda di Fagagna F. Telomere dysfunction in ageing and age-related diseases. Nat Cell Biol. 2022;24:135–47.
Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, et al. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 2012;4:691–704.
Pańczyszyn A, Boniewska-Bernacka E, Goc A. The role of telomeres and telomerase in the senescence of postmitotic cells. DNA Repair. 2020;95:102956.
Chilton WL, Marques FZ, West J, Kannourakis G, Berzins SP, O’Brien BJ, et al. Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS ONE. 2014;9: e92088.
Denham J, Sellami M. Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis. Ageing Res Rev. England; 2021;70:101411.
Smith EM, Pendlebury DF, Nandakumar J. Structural biology of telomeres and telomerase. Cell Mol Life Sci. 2020;77:61–79.
Lai T-P, Zhang N, Noh J, Mender I, Tedone E, Huang E, et al. A method for measuring the distribution of the shortest telomeres in cells and tissues. Nat Commun. 2017;8:1356.
Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet. 2003;33:203–7.
Bendix L, Horn PB, Jensen UB, Rubelj I, Kolvraa S. The load of short telomeres, estimated by a new method, Universal STELA, correlates with number of senescent cells. Aging Cell. 2010;9:383–97.
Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell. 2001;107:67–77.
Denham J. The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans. Biomed J. 2019;42:430–3.