- Original Research Article
- Open Access
Efficacy and Tolerability of Peritendinous Hyaluronic Acid in Patients with Supraspinatus Tendinopathy: a Multicenter, Randomized, Controlled Trial
© The Author(s). 2017
- Received: 15 December 2016
- Accepted: 25 May 2017
- Published: 5 June 2017
Physical therapy and peritendinous hyaluronic acid (HA) injections have both shown promising results in the treatment of shoulder tendinopathies. However, the superiority of treatment combining physical therapy and HA is unclear.
Patients with ultrasound-confirmed supraspinatus tendinopathy were randomized to receive either physical therapy + subacromial HA injections or physical therapy only. Treatment efficacy was assessed using a Visual Analog Scale (VAS) for pain and an Activities of Daily Living (ADL) scale. Other measures were the number of rehabilitation sessions and days needed for recovery, the Tampa Scale for Kinesiophobia (TSK), and the physician and patient’s perception of efficacy and tolerability. Patients were followed up for 90 days.
Overall, VAS and ADL scores showed a progressive decrease during the follow-up (P < 0.01 at all visits for both groups), without significant differences between groups. The TSK score decreased significantly more in the HA group than in the control group (3.6 vs. 2.4; P < 0.001). Patients in the control group needed more rehabilitation sessions (28 vs. 22 in the HA group; P = 0.006) and more days for returning to their pre-injury activity (32 vs. 20 in the HA group; P = 0.013). Both patients and investigators perceived higher efficacy in the HA group than in the control group (P = 0.034). Both treatments were safe and well tolerated.
Subacromial HA injections combined with physical therapy have high efficacy in the treatment of supraspinatus tendinopathy, leading to an earlier return to pre-injury activity and the need for fewer rehabilitation sessions, which may benefit both patients and the healthcare system.
Physical therapy is the gold-standard treatment for the management of tendinopathies.
In this study, we found that combined treatment with 2% hyaluronic acid injections and physical therapy promotes faster recovery in patients with supraspinatus tendinopathy.
Combined treatment with physical therapy and 2% hyaluronic acid may benefit the healthcare system and society by reducing rehabilitation costs and time off work.
Tendinopathy is a common injury in athletic populations, secondary to overuse [1, 2]. However, it may also occur in the overall population as a result of repetitive or excessive loading, and abnormal or unusual movements . Also, metabolic- and hormone-related clinical conditions such as diabetes, menopause, and adiposity have been identified as systemic risk factors for tendinopathies [4–6]. Although the incidence of tendinopathies in the overall population has not been established, different authors have reported a rising trend associated with increasing interest in sport activities in high-income societies [1, 2, 7].
The first-line pharmacological treatment for tendinopathies is most often based on non-steroidal anti-inflammatory drugs (NSAIDs), which are useful for pain control but may cause patients to ignore warning symptoms, resulting in further damage to the affected tendon [3, 8]. Intratendinous injections of corticosteroids are also common in the standard management of tendinopathies and appear to successfully reduce inflammation and pain at short-term; however, the risk-benefit ratio of their use in the treatment of tendinopathies is currently controversial [7, 9]. Owing to the limitations of pharmacological treatments in modifying the structure of the tendon, the management of tendinopathies usually includes other non-pharmacological interventions with proven benefits in tendon recovery such as relative rest, cold, ultrasound, and physical therapy, specifically eccentric style exercises and stretching to prevent stiffness [1, 3]. Other non-pharmacological interventions proposed include shock wave therapy, iontophoresis, sclerotherapy, and nitric oxide patches; however, results are not very consistent and multicenter trials are needed to confirm their efficacy. Among all of the physical therapeutic interventions, eccentric strengthening has shown remarkably good therapeutic outcomes in the treatment of various tendinopathies such as those affecting the patellar, Achilles, supraspinatus, and wrist tendons [1, 10–14].
Among the recent advances in the management of tendon disorders, the peritendinous administration of hyaluronic acid (HA) has shown promising results in clinical trials including patients with tennis elbow , patellar tendinopathy , Achilles tendinopathy [17, 18], and various disorders involving tendons in the rotator cuff [19–22]. HA is the primary component of synovial fluid and provides the joint with lubrication and shock absorption . Although the mechanisms of action in the treatment of tendinopathies are not well established, peritendinous injection of HA has shown to reduce tendon adhesion, provide mechanical protection, and upregulate the vascular endothelial growth factor and type IV collagen, resulting in the acceleration of tendon healing [24–26]. In the particular case of tendinopathies involving the rotator cuff, the use of HA injections led to a significant improvement of shoulder function in all published trials [19, 20, 22, 27, 28]. However, the superiority of HA over other interventions in scales assessing pain is controversial, and few studies have evaluated the efficacy of HA in the treatment of lesions affecting a particular tendon. In this regard, some authors have highlighted the need for further randomized trials to better establish which grade of lesions may benefit most from peritendinous injection of HA .
In this parallel-group, randomized, controlled trial, we investigated the efficacy and safety of peritendinous injection of HA in patients with persistent supraspinatus tendinopathy. To this end, we compared the therapeutic outcome of treatment with HA as an adjuvant to physical therapy with that of physical therapy as sole therapeutic intervention.
This was a prospective, randomized, open-label, parallel-group, phase IV trial to explore the efficacy of subacromial injection of HA as adjuvant treatment for supraspinatus tendinosis. Patients were recruited between March 2014 and August 2015 from four Spanish centers, including one general hospital and three sports medicine centers. The study protocol was approved by the ethics committee of the Catalan Sports Council (Barcelona, Spain), and all patients gave their written informed consent before entering the study. All data were managed in agreement with local personal data protection law (LOPD 15/1999).
Upon entering the study, patients were randomized into two study groups using the Random Allocation Software (version 1.0): the HA group was treated with physical therapy + subacromial injection of HA (40 mg sodium hyaluronate/2 mL, OSTENIL® TENDON, MW 1.6 MDa), and the control group was treated with physical therapy only. The exercise plan within the physical therapy standard of care (provided in the Additional file 1) was the same for both groups, and it was performed at a physiotherapy center under individual guidance. All patients started with three sessions per week, and the schedule was then tailored at physician discretion on the basis of patient progress. The physical therapy did not include any intervention based on physical energy. Patients in the HA group received two ultrasound-guided, subacromial bursa injections at the baseline visit and at day 7. Injections were performed with the patient in a sitting position and the injured arm on the back, in internal rotation. After identifying the inflamed subacromial bursa in the ultrasound image, the needle was inserted between the two bursa layers and the HA was gently injected. In the case of presence of liquid inside the bursa, a small amount of liquid was drawn before injecting the HA. All participants were urged not to undertake physical labor (e.g., bearing weight, practicing sports, overstraining, etc.) with the affected arm during the follow-up period. Concomitant treatment with NSAIDs (400 mg ibuprofen up to 1200 mg daily, according to the routine practice of participant centers) was permitted. Patients were followed up at days 7, 15, 30, and 90 after starting treatment. The patient discharge was considered at physician discretion based on the results of the ultrasound scanning.
The study population comprised subjects aged between 18 and 60 years with chronic, ultrasound-confirmed supraspinatus tendinopathy of at least 4 weeks duration and referring moderate pain (VAS score ≥6). Recruitment was limited to active subjects (i.e., those who performed daily physical labor in their workday and/or attended the gym at least 2–3 times a week, where they performed an aerobic activity for at least 50 min during each session, with at least three sessions per week). Patients who had undertaken physical rehabilitation for the same injury in the 6 months prior to the study were excluded from the record. Other exclusion criteria were the presence of systemic diseases, previous shoulder surgery, radiology-confirmed acromion type III in the Bigliani scale , and other shoulder injuries: fracture or dislocation, adhesive capsulitis, calcifying tendinopathy, total or partial rotator cuff tears, and acromioclavicular and/or glenohumeral joint diseases.
Study Endpoints and Variables
The primary endpoint was the assessment of efficacy using the American Shoulder and Elbow Surgeons (ASES) standardized shoulder assessment form [30–32]. The ASES form includes the evaluation of pain by means of the Visual Analog Scale (VAS) and the Activities of Daily Living (ADL) scale, which scores the difficulties for performing 10 everyday activities between 0 and 3. Secondary endpoints included indirect measures of efficacy such as the Tampa Scale for Kinesiophobia (TSK) , the number of rehabilitation sessions needed for recovery (i.e., absolute discharge, confirmed by ultrasound imaging, and return to daily activities, work and/or sporting activities), the number of days required to return to work or to sport activity, and physician and patient perception of the efficacy of the treatment received (rated on a 0–4 scale, where 0 was “very poor” and 4 was “excellent”). In addition to recording all adverse events occurring during the follow-up, the perception of patients and physicians on treatment tolerability was assessed on a 4-point scale. All variables were assessed at each visit.
The sample size was estimated considering a precision in the mean ASES score of 14.5 (average between 12 and 17, considered the minimum difference in the mean score to detect a relevant change in patients with rotator cuff disease ), and a standard deviation (SD) of 17.5 (the average reported in previous studies [30, 34]). Considering these assumptions, a study sample of at least 31 patients per group would provide a statistical power of 90% with a significance α level of 0.05.
The analysis was planned as an intention to treat analysis; hence, patients lost to follow-up after the first visit were included in the analysis. Continuous variables were summarized using means and measures of variance, whereas categorical variables were summarized using frequencies and percentages. The means of the baseline characteristics in each group were compared using the T test, whereas the percentages were compared using Fisher’s exact test. The differences in scores of the efficacy scales between the baseline and the other study visits within each group were assessed using the T test for paired samples, whereas differences between the study groups throughout the study were compared using an ANCOVA test. On the other hand, the perceptions of physicians and patients of tolerability and efficacy in each study group were compared using the non-parametric Mann-Whitney U test. The analysis was performed on available data only, and thus no imputations were done for missing values, which were eliminated pairwise. The significance threshold was set at a α value of 0.05, and all analyses were computed by an external statistical team (Onmedic) using the SAS System statistics software (Version 9.4.).
Baseline characteristics of study patients (percentages of patients in categorical variables were calculated for each group)
Age (years), mean (SD)
BMI (kg/m2), mean (SD)
Sex, n (%)
Affected shoulder, n (%)
VAS, mean (SD)
ADL, mean (SD)
TSK, mean (SD)
NSAID consumption during the last month, n (%)
Main Efficacy Scales
Indirect Measures of Efficacy
Tolerability and Safety
Based on patient perception, treatment with HA injections and physical therapy was tolerated equally to that based on physical therapy only (Fig. 3c). Accordingly, investigators rated the tolerability of both interventions equally during the first 15 days of treatment but considered that at days 30 and 90, treatment with HA and physical therapy had greater tolerability than physical therapy only (Fig. 3d).
During the follow-up period, 10 patients (12%) reported 13 adverse events, all of which were considered mild: 5 in the HA group, and 8 in the control group. Of 5 adverse events reported in the HA group, 4 were found to be related to treatment with HA, all of them pain after injection.
In this multicenter, parallel-group, randomized trial including patients with supraspinatus tendinopathy, we found that both physical therapy alone and physical therapy combined with subacromial HA injections had good tolerability and resulted in significant pain reduction and successful functional recovery. When compared to physical therapy only, patients treated with physical therapy and HA returned significantly earlier to work and needed fewer rehabilitation sessions.
The study groups were well balanced regarding the baseline demographic and clinic characteristics, including the prevalence of the affected shoulder, which was mostly the right one, as expected for an overuse injury. NSAID consumption was greater in the HA group; however, no significant differences arose between the two groups. Likewise, we did not observe significant differences in the baseline scores of the assessed scales, except the TSK, which was significantly higher in the HA group. The TSK has been little used in the assessment of HA treatment efficacy and measures the perceived threat of movement and expected pain in injured patients. In this regard, the fear of an injected treatment (not existing in the control group, as no placebo treatment was administered) could explain the discrepancy between the different TSK score and the homogeneity in other baseline measures of pain, such as the VAS score or NSAID consumption. Overall, the baseline scores of the TSK, VAS, and ADL scales revealed a moderate severity of the tendinopathy in our study patients.
After 90 days of follow-up, patients in both groups experienced a significant improvement in the VAS, ADL, and TSK scores, irrespective of the intervention received. This result is consistent with previous studies proving that treatment based solely on eccentric strengthening is sufficient for mid-term improvement in pain and function . When compared with physical therapy only, we found that the addition of treatment with subacromial HA significantly reduced the number of rehabilitation sessions and the treatment days needed for recovery. The reduction in the TSK score during the follow-up period was also greater and occurred earlier in the HA group, although the baseline differences between scores in each group might have influenced the differences observed during follow-up. In line with the better therapeutic outcome observed in the HA group, both patients and physicians rated significantly higher the efficacy of the combined treatment of physical therapy and subacromial HA than physical therapy only. In the case of physician perception, combined treatment was rated significantly higher than physical therapy from the first visit (day 7).
In light of the differences observed between study groups in the indirect measures of efficacy, we would also expect more remarkable differences between groups in treatment outcomes related to pain and the ability to perform ADL. However, NSAID consumption and the assessment of the VAS and ADL scores did not reveal significant differences between patients treated with physical therapy only and those treated with physical therapy and subacromial HA injections. Of note, as a clinical study performed on a medical device, the doses of concomitant medicines were not recorded, and therefore, no dose adjustment was performed in the comparative analysis. Considering the proven efficacy of physical therapy in the treatment of tendinopathies of the rotator cuff, it seems reasonable that a larger sample size would provide clearer differences between groups. Nevertheless, the superiority of HA treatment in pain improvement is unclear, and results in previous studies assessing the efficacy of HA injections in patients with tendinopathies affecting the rotator cuff are inconsistent. Merolla et al. found that HA monotherapy significantly reduced pain in more visits than physical therapy only , whereas Sengul et al. reported similar pain scores in patients receiving both interventions . Similar discrepancies have been found when investigating the efficacy of a combined treatment using HA injections and physical therapy. Thus, Meloni et al. concluded that rehabilitation exercises and HA injections were significantly more efficacious in pain reduction than the same exercises accompanied with placebo injections containing sodium chloride . On the other hand, Ozgen et al. compared the efficacy of HA injections with that of physical therapy and found no differences in pain improvement in most of the follow-up visits . Of note, the baseline VAS scores reported by Ozgen et al. in the study sample were remarkably small (below 1), which may have contributed to narrow the differences between groups. On the other hand, the ADL score has been barely assessed in trials investigating the efficacy of injected HA in patients with tendinopathies of the rotator cuff. In our study, all participants received clear instructions not to undertake physical labor with the affected arm until recovery. Such indication, not included in pivotal trials assessing the reliability of the ASES score [30, 31], allowed us to limit the bias related to the different jobs and activities performed by each patient; however, it was likely to influence the overall ADL score, as patients may have limited their day-to-day activities, regardless of their functional recovery and pain.
In line with safety data previously reported in the literature [19, 20, 22], both interventions were safe and well tolerated, with a 12% rate of adverse events rate—all of them mild—, mostly reported by patients in the control group. Furthermore, both patients and physicians rated tolerability over 2.5 points on a 4-point Likert scale during the entire follow-up. Perceived tolerability progressively increased throughout the follow-up period, and no significant differences were observed between the study groups.
The main limitation of our study is the lack of control groups. Unlike other studies, aimed at investigating the efficacy of HA injections alone, our objective was to compare the combined treatment with the gold-standard for the management of tendinopathies. The presence of a placebo group with non-active peritendinous injections might have limited possible biases, particularly in patient-reported efficacy. Accordingly, the inclusion of a sham physical therapy would have yielded more extreme differences between groups. However, including more than two intervention groups would have dramatically reduced the size of each group. In fact, the final sample size (84 patients) was larger than that in most studies assessing the efficacy of HA injections in tendinopathies of the rotator cuff , but it still limited the observation of significant differences in some scales. Along the same lines, the open-label HA administration may introduce a bias in both the physician and patient efficacy assessment. Finally, due to the sample size limitations, all centers were considered as a whole and no cluster analyses were performed to explore the center bias.
Despite the limitations of our study, the results obtained in most of the assessed scales are consistent and support the use of subacromial HA injections as adjuvant treatment to physical therapy in the management of supraspinatus tendinopathy. In our experience, treatment based only on physical therapy was sufficient to reduce pain and improve function. In addition, the combination of physical therapy with subacromial HA reduced the number of rehabilitation sessions and recovery time. These findings suggest that combined treatment with physical therapy and HA may not only increase patients’ quality of life but it might also benefit the healthcare system and society by reducing rehabilitation costs and time off work.
Authors would like to thank Montse Pujol, Fernando García, and Jaume Pérez for their assistance in patient recruitment and data collection. Authors would like to thank Onmedic Networks S.L. for help with statistical analysis and Gerard Carot-Sans (PhD) for providing medical writing assistance during the preparation of the manuscript.
Funding was received from OPKO Health Spain S.L.U., which also provided the medical devices used in the study.
Ramon Balius has received consulting fees for the study plan and financial support for travel to meetings for the study from OPKO Health Spain, S.L.U.; Guillermo Álvarez and Miguel A. Buil have received financial support for travel to meetings for the study from OPKO Health Spain, S.L.U.; Luisa Varela and Joaquín Casariego are employed by OPKO Health Spain, S.L.U. as Clinical Research Manager and Medical Director, respectively. César Flores and Carlos Cano declare that they have no conflicts of interest.
CF, RB, GA, MAB, LV, and CC were responsible for the study conception and design. CF, RB, GA, MAB, and CC were responsible for the data collection. RB, LV, and JC analyzed the dataset. CF, RB, MAB, LV, CC, and JC drafted the original form of the manuscript. GA, LV, and JC performed critical revision of the manuscript drafts. All authors read and approved the final version of the manuscript.
Consent for publication
Informed consent was obtained from all individual participants included in the study.
Ethics approval and consent to participate
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Andres BM, Murrell GAC. Treatment of tendinopathy: what works, what does not, and what is on the horizon. Clin Orthop Relat Res. 2008;466:1539–54.View ArticlePubMedPubMed CentralGoogle Scholar
- Renstrom P, Woo SL. Tendinopathy: a major medical problem in sport. Tendinopathy in athletes. Oxford, UK: Blackwell Publishing Ltd; 2008. p. 1–9.Google Scholar
- Kaux JF, Forthomme B, le Goff C, Crielaard JM, Croisier JL. Current opinions on tendinopathy. J Sport Sci Med. 2011;10:238–53.Google Scholar
- Frizziero A, Vittadini F, Gasparre G, Masiero S. Impact of oestrogen deficiency and aging on tendon: concise review. Muscles Ligaments Tendons J. 2014;4:324. CIC Edizioni internazionali.PubMedPubMed CentralGoogle Scholar
- Oliva F, Piccirilli E, Berardi AC, Frizziero A, Tarantino U, Maffulli N. Hormones and tendinopathies: the current evidence. Br Med Bull. 2016;117:39–58. British Council.View ArticlePubMedGoogle Scholar
- Frizziero A, Salamanna F, Della Bella E, Vittadini F, Gasparre G, Aldini NN, et al. The role of detraining in tendon mechanobiology. Front Aging Neurosci. 2016;8:43. doi:10.3389/fnagi.2016.00043.
- Maffulli N, Longo UG, Loppini M, Spiezia F, Denaro V. New options in the management of tendinopathy. Open access J Sport Med. 2010;1:29–37.View ArticleGoogle Scholar
- Magra M, Maffulli N. Nonsteroidal antiinflammatory drugs in tendinopathy: friend or foe. Clin J Sport Med. 2006;16:1–3.View ArticlePubMedGoogle Scholar
- Coombes BK, Bisset L, Vicenzino B. Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials. Lancet. 2010;376:1751–67.View ArticlePubMedGoogle Scholar
- Reinking M. Tendinopathy in athletes. Phys Ther Sport. 2012;13:3–10.View ArticlePubMedGoogle Scholar
- Stanish WD, Rubinovich RM, Curwin S. Eccentric exercise in chronic tendinitis. Clin Orthop Relat Res. 1986;208:65–8. LWW.Google Scholar
- Jonsson P, Alfredson H. Superior results with eccentric compared to concentric quadriceps training in patients with jumper’s knee: a prospective randomised study. Br J Sports Med. 2005;39:847–50.View ArticlePubMedPubMed CentralGoogle Scholar
- Bahr R, Fossan B, Loken S, Engebretsen L. Surgical treatment compared with eccentric training for patellar tendinopathy (Jumper ’ s Knee). J bone Jt Surg. 2006;88–A:1689–98.Google Scholar
- Dimitrios S, Pantelis M, Kalliopi S. Comparing the effects of eccentric training with eccentric training and static stretching exercises in the treatment of patellar tendinopathy. A controlled clinical trial. Clin Rehabil. 2012;26:423–30.View ArticlePubMedGoogle Scholar
- Petrella RJ, Cogliano A, Decaria J, Mohamed N, Lee R. Management of tennis elbow with sodium hyaluronate periarticular injections. Sports Med Arthrosc Rehabil Ther Technol. 2010;2:4.PubMedPubMed CentralGoogle Scholar
- Muneta T, Koga H, Ju YJ, Mochizuki T, Sekiya I. Hyaluronan injection therapy for athletic patients with patellar tendinopathy. J Orthop Sci. 2012;17:425–31.View ArticlePubMedGoogle Scholar
- Kumai T, Muneta T, Tsuchiya A, Shiraishi M, Ishizaki Y, Sugimoto K, et al. The short-term effect after a single injection of high-molecular-weight hyaluronic acid in patients with enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis): a preliminary study. J Orthop Sci. 2014;19:603–11. Springer.View ArticlePubMedGoogle Scholar
- Petrella MJ, Cogliano A, Petrella RJ. Original research: long-term efficacy and safety of periarticular hyaluronic acid in acute ankle sprain. Phys Sportsmed. 2009;37:64–70.View ArticlePubMedGoogle Scholar
- Merolla G, Bianchi P, Porcellini G. Ultrasound-guided subacromial injections of sodium hyaluronate for the management of rotator cuff tendinopathy: a prospective comparative study with rehabilitation therapy. Musculoskelet Surg. 2013;97:49–56.View ArticlePubMedGoogle Scholar
- Meloni F, Milia F, Cavazzuti M, Doria C, Lisai P, Profili S, et al. Clinical evaluation of sodium hyaluronate in the treatment of patients with sopraspinatus tendinosis under echographic guide: experimental study of periarticular injections. Eur J Radiol. 2008;68:170–3.View ArticlePubMedGoogle Scholar
- Kim YS, Park JY, Lee CS, Lee SJ. Does hyaluronate injection work in shoulder disease in early stage? A multicenter, randomized, single blind and open comparative clinical study. J Shoulder Elb Surg. 2012;21:722–7.View ArticleGoogle Scholar
- Sengul I, Oz B, Yoleri O, Olmez N, Memis A, Uluç E. Sodium hyaluronate injections compared to local modalities for the treatment of shoulder impingement syndrome/Omuz sikisma sendromu tedavisinde sodyum hiyaluronat enjeksiyonu ile lokal modalitelerin karsilastirilmasi. Turk J Phys Med Rehab 2008; 54:138–43.Google Scholar
- Moreland LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther. 2003;5:54–67.View ArticlePubMedPubMed CentralGoogle Scholar
- Riccio M, Battiston B, Pajardi G, Corradi M, Passaretti U, Atzei A, et al. Efficiency of Hyaloglide in the prevention of the recurrence of adhesions after tenolysis of flexor tendons in zone II: a randomized, controlled, multicentre clinical trial. J Hand Surg Eur Vol. 2010;35:130–8.View ArticlePubMedGoogle Scholar
- Yagishita K, Sekiya I, Sakaguchi Y, Shinomiya K, Muneta T. The effect of hyaluronan on tendon healing in rabbits. Arthrosc J Arthrosc Relat Surg. 2005;21:1330–6. Elsevier.View ArticleGoogle Scholar
- Halici M, Karaoglu S, Canoz O, Kabak S, Baktir A, Petrella MJ, et al. Sodium hyaluronate regulating angiogenesis during Achilles tendon healing. Knee Surg Sport Traumatol Arthrosc. 2004;12:562–7.View ArticleGoogle Scholar
- Osti L. Clinical evidence in the treatment of rotator cuff tears with hyaluronic acid. Muscles Ligaments Tendons J. 2015;5:270–5.PubMedGoogle Scholar
- Ozgen M, Fırat S, Sarsan A, Topuz O, Ardıç F, Baydemir C. Short- and long-term results of clinical effectiveness of sodium hyaluronate injection in supraspinatus tendinitis. Rheumatol Int. 2012;32:137–44.View ArticlePubMedGoogle Scholar
- Bigliani LU. The morphology of the acromion and its relationship to rotator cuff tears. Orthop Trans. 1986;10:228.Google Scholar
- Kocher MS, Horan MP, Briggs KK, Richardson TR, O’Holleran J, Hawkins RJ. Reliability, validity, and responsiveness of the American Shoulder and Elbow Surgeons subjective shoulder scale in patients with shoulder instability, rotator cuff disease, and glenohumeral arthritis. J Bone Jt Surg Am. 2005;87:2006–11.Google Scholar
- Richards RR, An KN, Bigliani LU, Friedman RJ, Gartsman GM, Gristina AG, et al. A standardized method for the assessment of shoulder function. J Shoulder Elb Surg. 1994;3:347–52.View ArticleGoogle Scholar
- Roy JS, Macdermid JC, Woodhouse LJ. Measuring shoulder function: a systematic review of four questionnaires. Arthritis Care Res. 2009;61:623–32.View ArticleGoogle Scholar
- Gómez-Pérez L, López-Martínez AE, Ruiz-Párraga GT. Psychometric properties of the spanish version of the Tampa Scale for kinesiophobia (TSK). J Pain. 2011;12:425–35.View ArticlePubMedGoogle Scholar
- Tashjian RZ, Deloach J, Green A, Porucznik CA, Powell AP. Minimal clinically important differences in ASES and simple shoulder test scores after nonoperative treatment of rotator cuff disease. J Bone Jt Surg. 2010;92:296–303.View ArticleGoogle Scholar