Wållberg M, Cooke A. Immune mechanisms in type 1 diabetes. Trends Immunol. 2013;34:583–91.
Article
PubMed
Google Scholar
Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. 2003;2:119–25.
Article
PubMed
Google Scholar
The autoimmune diseases coordinating committee (ADCC). Progress in Autoimmune Diseases Research Progress. Bethesda: National Institutes of Health; 2005. p. 1–129.
Forlenza GP, Rewers M. The epidemic of type 1 diabetes: what is it telling us? Curr Opin Endocrinol Diabetes Obes [Internet]. 2011;18:248–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21844707.
Article
Google Scholar
Egro FM. Why is type 1 diabetes increasing? J Mol Endocrinol. 2013;51:R1–13.
Antico A, Tampoia M, Tozzoli R, Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev. 2012;12:127–36.
Bach JF, Chatenoud L. The hygiene hypothesis: an explanation for the increased frequency of insulin-dependet diabetes. Cold Spring Harb Perspect Med. 2012;2:1–10.
Article
Google Scholar
Ludwig DS. Relation between consumption of sugar sweetened drinks and childhood obesity: a prospective observational analysis. Lancet. 2001;357:505–8.
Article
CAS
PubMed
Google Scholar
Ayer J, Charakida M, Deanfield JE, Celermajer DS, Ng M, Fleming T, et al. Lifetime risk: childhood obesity and cardiovascular risk. Eur Heart J. 2015;36:1371–6.
Downing KL, Hnatiuk J, Hesketh KD. Prevalence of sedentary behavior in children under 2 years: a systematic review. Prev Med (Baltim). 2015;78:105–14.
Noutsios GT, Floros J. Childhood asthma: causes, risks, and protective factors; a role of innate immunity. Swiss Med Wkly. 2014;144:w14036.
Dahlquist G. Can we slow the rising incidence of childhood-onset autoimmune diabetes? The overload hypothesis. Diabetologia. 2006;49:20–4.
Article
CAS
PubMed
Google Scholar
Bonaccio M, Pounis G, Cerletti C, Donati MB, Iacoviello L, de Gaetano G. Mediterranean diet, dietary polyphenols and low-grade inflammation: results from the moli-sani study. Br J Clin Pharmacol. 2016;83:107–13.
Sahebkar A. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phyther Res. 2014;28:633–42.
Article
CAS
Google Scholar
Shehzad A, Rehman G, Lee YS. Curcumin in inflammatory diseases. BioFactors. 2013;39:69–77.
Article
CAS
PubMed
Google Scholar
Srivastava RM, Singh S, Dubey SK, Misra K, Khar A. Immunomodulatory and therapeutic activity of curcumin. Int Immunopharmacol. 2011;11:331–41.
Ji LL, Zhang Y. Antioxidant and anti-inflammatory effects of exercise: role of redox signaling. Free Radic Res. 2013;48:1–9.
Nielsen S, Pedersen BK. Skeletal muscle as an immunogenic organ. Curr Opin Pharmacol. 2008;8:346–51.
Article
CAS
PubMed
Google Scholar
Wasinski F, Gregnani MF, Ornellas FH, Bacurau AVN, Câmara NO, Araujo RC, et al. Lymphocyte glucose and glutamine metabolism as targets of the anti-inflammatory and immunomodulatory effects of exercise. Mediators Inflamm. 2014;2014:1–10.
Ringeis R, Eder K, Mooren FC, Kruger K. Metabolic signals and innate immune activation in obesity and exercise. Exerc Immunol Rev. 2015;21:58–68.
Google Scholar
Driver JP, Serreze DV, Chen Y-G. Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol. 2011;33:67–87.
Pearson JA, Wong FS, Wen L. The importance of the non obese diabetic (NOD) mouse model in autoimmune diabetes. J Autoimmun. 2016;66:76–88.
Ventura-Oliveira D, Vilella CA, Zanin ME, Castro GM, Moreira Filho DC, Zollner RL. Kinetics of TNF-alpha and IFN-gamma mRNA expression in islets and spleen of NOD mice. Brazilian J Med Biol Res. 2002;35:1347–55.
Article
CAS
Google Scholar
Wang JL, Qian X, Chinookoswong N, John L, Chow G, Theill LE, et al. Polyethylene glycolated recombinant TNF receptor I improves insulitis and reduces incidence of spontaneous and cyclophosphamide-accelerated diabetes in nonobese diabetic mice. Endocrinology. 2002;143:3490–7.
Article
CAS
PubMed
Google Scholar
Kägi D, Ho A, Odermatt B, Zakarian A, Ohashi PS, Mak TW. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. J Immunol. 1999;162:4598–605.
PubMed
Google Scholar
Pakala SV, Chivetta M, Kelly CB, Katz JD. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. J Exp Med. 1999;189:1053–62.
Chee J, Angstetra E, Mariana L, Graham KL, Carrington EM, Bluethmann H, et al. TNF receptor 1 deficiency increases regulatory T cell function in nonobese diabetic mice. J Immunol. 2011;187:1702–12.
Fu Z, Yuskavage J, Liu D. Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice. J Agric Food Chem. 2013;61:4303–9.
Fu Z, Zhen W, Yuskavage J, Liu D. Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice. Br J Nutr. 2011;105:1218–25.
Article
CAS
PubMed
Google Scholar
Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the american institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939–51.
CAS
PubMed
Google Scholar
National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals. 8th edition. Washington (DC): National Academies Press (US); 2011. Available from: https://www.ncbi.nlm.nih.gov/books/NBK54050/. doi:10.17226/12910.
Reddy S, Chai RCC, Rodrigues JA, Hsu TH, Robinson E. Presence of residual beta cells and co-existing islet autoimmunity in the NOD mouse during longstanding diabetes: a combined histochemical and immunohistochemical study. J Mol Histol. 2008;39:25–36.
Article
CAS
PubMed
Google Scholar
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.
Zhang C, Todorov I, Lin C-L, Atkinson M, Kandeel F, Forman S, et al. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci USA. 2007;104:2337–42.
Signore A, Annovazzi A, Giacalone P, Beales PE, Valorani MG, Vestri AR, et al. Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice. Diabetes Metab Res Rev. 2003;19:464–8.
Article
CAS
PubMed
Google Scholar
Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB, Anand P, Kunnumakkara AB, et al. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807–18.
Article
CAS
PubMed
Google Scholar
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, et al. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease. J Pharmacol Exp Ther. 2008;326:196–208.
Article
CAS
PubMed
PubMed Central
Google Scholar
Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. 2014;32:1053–64.
Zhang D-W, Fu M, Gao S-H, Liu J-L. Curcumin and diabetes: a systematic review. Evid Based Complement Alternat Med. 2013;2013:1–6.
Castro CN, Barcala Tabarrozzi AE, Winnewisser J, Gimeno ML, Antunica Noguerol M, Liberman AC, et al. Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes. Clin Exp Immunol. 2014;177:149–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marietta EV, Gomez AM, Yeoman C, Tilahun AY, Clark CR, Luckey DH, et al. Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiome. PLoS One. 2013;8:1–9.
Article
Google Scholar
Hoorfar J, Buschard K, Dagnaes-Hansen F. Prophylactic nutritional modification of the incidence of diabetes in autoimmune non-obese diabetic (NOD) mice. Br J Nutr. 1993;69:597–607.
Article
CAS
PubMed
Google Scholar
Odegaard JI, Chawla A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science. 2013;339:172–7.
Pane JA, Fleming FE, Graham KL, Thomas HE, Kay TWH, Coulson BS. Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling. Sci Rep. 2016;6:1–12.
Morgado JM, Rama L, Silva I, Inácio De Jesus M, Henriques A, Laranjeira P, et al. Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers. Eur J Appl Physiol. 2012;112:471–82.
Article
CAS
PubMed
Google Scholar
Nickel T, Emslander I, Sisic Z, David R, Schmaderer C, Marx N, et al. Modulation of dendritic cells and toll-like receptors by marathon running. Eur J Appl Physiol. 2012;112:1699–708.
Article
CAS
PubMed
Google Scholar
Deckx N, Wens I, Nuyts AH, Hens N, De Winter BY, Koppen G, et al. 12 weeks of combined endurance and resistance training reduces innate markers of inflammation in a randomized controlled clinical trial in patients with multiple sclerosis. Mediators Inflamm. 2016;2016:1–13. Hindawi Publishing Corporation.
MacKenzie B, Andrade-Sousa AS, Oliveira-Junior MC, Assumpção-Neto E, Alves-Rangel MB, Silva Renno A, et al. Dendritic cells are involved in the effects of exercise in a model of asthma. Med Sci Sport Exerc. 2016;48:1459–67.
Pedersen BK, Toft AD. Effects of exercise on lymphocytes and cytokines. Br J Sports Med. 2000;34:246–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pedersen BK, Brandt C. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. J Biomed Biotechnol. 2010;2010:1–6.
Paula FMM, Leite NC, Vanzela EC, Kurauti MA, Freitas-Dias R, Carneiro EM, et al. Exercise increases pancreatic β-cell viability in a model of type 1 diabetes through IL-6 signaling. FASEB J. 2015;29:1805–16.