Obesity-Related Genetic Variants and their Associations with Physical Activity

Sports Medicine - Open

Table 3 Genotype frequencies of single nucleotide polymorphisms for FAMuSS participants

Gene	RefSeq#	Alleles (+/−)	Obesity risk allele^a	Obesity risk allele frequency in FAMuSS (+)	Published obesity risk allele frequency for CEU (+)^b
MC4R	rs17782313	T/C	C	0.790	0.735
TMEM18	rs6548238	C/T	C	0.824	0.850
FTO	rs9939609	T/A	A	0.395	0.460
NEGR1	rs2815752	A/G	A	0.650	0.637
SH2B1	rs7498665	A/G	G	0.392	0.381
KCTD15	rs11084753	G/A	G	0.664	0.690

CEU European Caucasian, SNPs single nucleotide polymorphisms, FAMuSS Functional SNPs Associated with Muscle Size and Strength, MC4R melanocortin 4 receptor, TMEM18 transmembrane protein 18, FTO fat mass and obesity-associated gene, NEGR1 neuronal growth regulator 1, SH2B1 Src homology 2B adapter protein 1, KCTD15 potassium channel tetramerization domain containing 15
^aAccording to Willer et al. [16]
^bUtah residents with northern western European ancestry from the Center for the Study of Human Polymorphisms (CEPH) collection used in haplotype map (HapMap)