Table 1 Baseline and 12 months: characteristics of the patients who finished the 12-month follow-up
From: Exercise and Prediabetes After Renal Transplantation (EXPRED-I): A Prospective Study
Overall | Prediabetes 12 months | Normal 12 months | |
|---|---|---|---|
N | 27 | 11 | 16 |
Baseline | |||
Age (years) | 54 ± 10 | 54 ± 10.4 | 54.3 ± 9.4 |
Gender (male-%) | 18 (67) | 8 (73) | 10 (63) |
Weight (kg) | 88.4 ± 19.7 | 92.4 ± 15 | 85.6 ± 22.4 |
Height (cm) | 168.3 ± 11.4 | 168.7 ± 11 | 168 ± 12 |
BMI (kg/m2) | 30.9 ± 4.7 | 32.5 ± 4.2 | 30 ± 5 |
> 30 (kg/m2) | 17 (63) | 8 (73) | 9 (56) |
Hip (cm) | 104.1 ± 14.2 | 106 ± 12.4 | 102.8 ± 15.6 |
Waist (cm) | 107.2 ± 12 | 111 ± 12 | 104.3 ± 11.3 |
Waist to hip ratio | 1.04 ± 0.11 | 1.01 ± 0.1 | 1 ± 0.1 |
OGTT | |||
Glucose 0’ (mg/dL) | 104.1 ± 12.1 | 107.1 ± 13.4 | 102.13 ± 11 |
Glucose 120’ (mg/dL) | 168.1 ± 51.5 | 188.1 ± 69.4 | 154.44 ± 30 |
IFG n, % | 16 (59) | 7 (64) | 9 (56) |
IGT n, % | 22 (81) | 10 (91) | 12 (75) |
IFG and IGT n, % | 11 (41) | 6 (55) | 5 (31) |
Insulin sensitivity | |||
Matsuda index | 4.2 [2.9–6.4] | 4.2 [2.5–7.8] | 4.3 [2.8–6.7] |
Stumvoll index | 0.06 [0.04–0.08] | 0.05 [0.02–0.08] | 0.06 [0.04–0.08] |
Systolic BP (mmHg) | 140.9 ± 17.1 | 141 ± 14.8 | 140.9 ± 18.4 |
Diastolic BP (mmHg) | 78.4 ± 8.3 | 82.8 ± 4.6 | 75.3 ± 8.4a |
Total Chol (mg/dL) | 177.6 ± 28.8 | 169.8 ± 32.6 | 182.9 ± 25.7 |
Triglycerides (mg/dL) | 151.4 ± 61.9 | 147.7 ± 65.9 | 153.9 ± 61.1 |
Previous CV events | 7 (25%) | 4 (36%) | 3 (18%) |
Family history of DM | 6 (22%) | 2 (9%) | 4 (25%) |
HbA1c (%) | 5.9 ± 0.3 | 6.1 ± 0.4 | 5.8 ± 0.2 |
Uric acid (mg/dL) | 5.8 ± 1.6 | 6 ± 1.5 | 5.6 ± 1.7 |
Creatinine (mg/dL) | 1.30 ± 0.3 | 1.32 ± 0.3 | 1.29 ± 0.3 |
Estimated GFR (mg/dL) | 58 ± 14.3 | 57.6 ± 14.8 | 58.4 ± 14.3 |
12 months | |||
Weight (kg) | 83.3 ± 19.4 | 87.4 ± 14.3 | 83.3 ± 22.2 |
BMI (kg/m2) | 29.1 ± 4.5 | 30.7 ± 3.6 | 28.0 ± 4.8 |
> 30 (kg/m2) | 14 (52) | 8 (73) | 6 (37) |
Hip (cm) | 95.6 ± 14.3 | 99.0 ± 12.5 | 93.2 ± 15.4 |
Waist (cm) | 98.7 ± 9.9 | 101.5 ± 7.7 | 96.7 ± 10.9 |
Waist to hip ratio | 1.04 ± 0.1 | 1.04 ± 0.1 | 1.05 ± 0.1 |
OGTT | |||
Glucose 0’ (mg/dL) | 90.4 ± 9.8 | 95.82 ± 9.8 | 86.75 ± 6.9b |
Glucose 120’ (mg/dL) | 127.5 ± 31.2 | 153.3 ± 27.4 | 113.0 ± 23.1c |
Insulin sensitivity | |||
Matsuda index | 6.1 [4–10.1] | 2.8 [2.4–5.3] | 6.5 [6–12]d |
Stumvoll index | 0.08 [0.05–0.09] | 0.04 [0.01–0.07] | 0.09 [0.08–0.11]e |
SBP (mmHg), range | 127.8 ± 12.1 | 129.9 ± 7.7 | 126.3 ± 14.5 |
DBP (mmHg), range | 73.4 ± 7.3 | 77.6 ± 6.7 | 70.5 ± 6.4 |
Total Chol (mg/dL) | 166 ± 28.4 | 157 ± 28.2 | 172.5 ± 27.6 |
Triglycerides (mg/dL) | 113 ± 45.3 | 138 ± 55.9 | 95.7 ± 26.6f |
HbA1c (%) | 6 ± 0.4 | 6.2 ± 0.5 | 5.8 ± 0.2 g |
Uric acid (mg/dL) | 5.9 ± 1.7 | 6.3 ± 1.5 | 5.5 ± 1.7 |
Creatinine (mg/dL) | 1.27 ± 0.3 | 1.35 ± 0.3 | 1.21 ± 0.3 |
Estimated GFR (mg/dL) | 60 ± 14.9 | 56.2 ± 13.8 | 62.6 ± 15.4 |
Medication | |||
Prednisone (n-%) | 27 (100%) | 11 (100%) | 16 (100%) |
Tacrolimus (n-%) | 27 (100%) | 11 (100%) | 16 (100%) |
Mycophenolate (n-%) | 20 (75%) | 8 (72%) | 12 (75%) |
Everolimus (n-%) | 7 (25%) | 3 (27%) | 4 (25%) |
Post-tx years | 5.6 [2.2–12.5] | 5.6 [2.2–11.6] | 6 [2–18.7] |