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Table 7 Training or race-related illness and injury

From: Is There Evidence for the Development of Sex-Specific Guidelines for Ultramarathon Coaches and Athletes? A Systematic Review

Study

Participants

Measures

Design

Evidence quality

Major findings

Hoffman & Krishnan [52]

1,212 active ultramarathon athletes (32% female, 68% male). Median age 42.3 years (range 18–81 years)

12-month incidence of exercise-related injury and stress fractures

Cohort study

Low

No sex differences in rate of exercise-related injuries over 12-month period. Stress fractures were more common among females, compared with males (p < 0.001)

Khodaee et al

(Abstract only) [57]

308 athletes who completed a 100 mile ultramarathon. Sex split not reported

Race-related injuries requiring medical attention post-race

Cross-sectional

Low

No sex differences in incidence of race-related injuries requiring medical attention

Krabak et al.[53]

396 athletes (20.8% females, 79.2% males) who completed a 250 km 7-day trail ultramarathon

Rate of medical illness and injury

Cohort study

Low

Females were 16% more likely to encounter medical illness when adjusted for age and race hours

No difference in overall injury/illness rates, skin problems, or MSK injuries

Lipman et al.[54]

128 athletes

(28% females and 72% males) who competed in a 250 km multi-stage ultramarathon

Changes in serum creatinine, cumulative incidence and prevalence of AKI

Cohort study

Low

Overall cumulative incidence of AKI was 41.4%. Odds ratio for females and AKI was 4.64 (95% CI 2.07–10.37, p < 0.001)

Hoffman et al.[58]

201 athletes who completed a 161 km ultramarathon. Sex split not reported

Plasma sodium, incidence of EAH

Cohort study

Low

Overall EAH incidence was 6%. No sex differences in incidence of EAH

Rust et al.[59]

46 athletes

(19 females and 27 males) who completed a 100 km ultramarathon

Body mass,

plasma and urinary electrolytes,

Hct, plasma volume,

fluid, energy, and electrolyte intake

Cohort study

Low

5% (n = 1) of females and 11% of males (n = 3) developed EAH. Significant decrease in Hct in females (-1.2%, p > 0.05) but not in males (-1.1%, p < 0.05). No sex differences in electrolyte changes

Hoffman et al.[62]

47 athletes

(Sex split not reported) who completed a 161 km ultramarathon

Serum sodium

Cohort study

Low

Overall EAH incidence was 30%

Females made up 28.6% of hyponatraemic group and 18.2% of normonatraemic group (significant > 0.05)

Chlibkova et al.[60]

113 athletes

(25 females and 88 males) who completed an ultramarathon

Serum sodium

Cohort study

Low

No sex differences in the incidence of hyponatraemia

Costa et al.[61]

74 athletes

(28 females and 46 males) who completed a 225 km multi-stage ultramarathon

Mean age 41 years

Fluid and sodium intake,

serum sodium and osmolality, plasma volume,

urine osmolality

Cohort study

Low

Females had a higher water intake (daily and during running) when corrected for body mass (p < 0.001). No significant sex differences in sodium intake, serum sodium, plasma volume, serum osmolality

Khodaee et al.[63]

84 athletes

(15 females and 69 males) who competed in a 100 mile high altitude ultramarathon in Colorado

Serum sodium, post-race survey

Cohort study

Low

15.9% of males had EAH, compared with 40% of females (p = 0.66)

Schwellnus et al.[56]

49 athletes who completed a 56 km ultramarathon

Incidence of EAMC

Cohort study

Low

No sex differences of EAMC incidence during, or within 6 h of an ultramarathon

Bouscaren et al.[55]

3126 athletes (525 females and 2601 males) who competed in a trail ultramarathon on Reunion Island. Mean age 42.2 years

Pre- and post-race survey

Cohort study

Low

History of HRI: 79.9% of males vs 70.2% of females (p < 0.001)

History of muscle cramps: 40.9% of males vs 22.5% of females (p < 0.001). No significant sex differences in history of digestive issues, headaches, or collapse

Experienced heat-related symptoms during race: 56.5% of males vs 46.8% of females (p = 0.002)

  1. MSK, musculoskeletal; AKI, acute kidney injury; Hct, haematocrit; EAH, exercise-associated hyponatraemia; HRI, heat-related illness; and EAMC, exercise-associated muscle cramps