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Table 5 Sensitivity analysis for all COL5A1 comparisons

From: Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Comparison Genetic model S A B
Homozygous Recessive Dominant Codominant
All
 rs12722 Robust* Robust* Robust Robust 2 0 4
 rs13946 [31]a [31]b [31]b [26] [26, 30] 0 4 0
Modifier
 rs12722 HWE Robust* Robust Robust Robust 1 0 4
 rs13946 HWE [26, 32] [26, 32] [26] [31]a 0 3 0
Subgroup
 rs12722 tendon [31]b [31]b Robust [26, 28] [31]b 0 3 1
 rs13946 tendon [31]a [26] Robust [31]a [31]b 0 3 1
 rs12722 ligament Robust* Robust* [29, 30, 32] Robust* 3 3 3
 rs13946 ligament Robust Robust [30] [30] 0 1 2
Other COL5A1 polymorphisms
 rs71746744 Robust* Robust Robust* Robust* 3 0 4
 rs16399 Robust* Robust* Robust* Robust* 4 0 4
 rs3196378 [27] Robust Robust Robust 0 1 3
Post-outlier
 All
  rs12722 Robust* Robust* Robust* 3 0 3
  rs13946 Robust* Robust* [31]a Robust 2 1 3
 Modifier
  rs12722 HWE Robust* Robust* Robust* 3 0 3
  rs13946 HWE [31]a [31]a [31]a [31]a 0 1 0
 Subgroup
  rs12722 tendon [31]b Robust* Robust* Robust* 3 1 3
  rs13946 tendon Robust* Robust* [31]a Robust 2 1 3
  rs12722 ligament [29, 30, 32] 0 3 0
  rs13946 ligament [30] [32] [30] [30] 0 2 0
S 7 8 5 6    
A 6 4 5 5    
B 8 12 10 11    
Total number of comparisons 16 18 19 18    
  1. HWE Hardy–Weinberg Equilibrium, S number of significant associations, A number of non-redundant references that contributed to instability, B number of robust findings
  2. *Significant associations
  3. [31]a AU; [31]b SA