Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Sports Medicine - Open

Table 5 Sensitivity analysis for all COL5A1 comparisons

Comparison	Genetic model				S	A	B
Comparison	Homozygous	Recessive	Dominant	Codominant	S	A	B
All
rs12722	Robust*	Robust*	Robust	Robust	2	0	4
rs13946	[31]^a [31]^b	[31]^b	[26]	[26, 30]	0	4	0
Modifier
rs12722 HWE	Robust*	Robust	Robust	Robust	1	0	4
rs13946 HWE	[26, 32]	[26, 32]	[26]	[31]^a	0	3	0
Subgroup
rs12722 tendon	[31]^b	[31]^b	Robust	[26, 28] [31]^b	0	3	1
rs13946 tendon	[31]^a	[26]	Robust	[31]^a [31]^b	0	3	1
rs12722 ligament	Robust*	Robust*	[29, 30, 32]	Robust*	3	3	3
rs13946 ligament	Robust	Robust	[30]	[30]	0	1	2
Other COL5A1 polymorphisms
rs71746744	Robust*	Robust	Robust*	Robust*	3	0	4
rs16399	Robust*	Robust*	Robust*	Robust*	4	0	4
rs3196378	[27]	Robust	Robust	Robust	0	1	3
Post-outlier
All
rs12722	–	Robust*	Robust*	Robust*	3	0	3
rs13946	Robust*	Robust*	[31]^a	Robust	2	1	3
Modifier
rs12722 HWE	–	Robust*	Robust*	Robust*	3	0	3
rs13946 HWE	[31]^a	[31]^a	[31]^a	[31]^a	0	1	0
Subgroup
rs12722 tendon	[31]^b	Robust*	Robust*	Robust*	3	1	3
rs13946 tendon	Robust*	Robust*	[31]^a	Robust	2	1	3
rs12722 ligament	–	–	[29, 30, 32]	–	0	3	0
rs13946 ligament	[30]	[32]	[30]	[30]	0	2	0
S	7	8	5	6
A	6	4	5	5
B	8	12	10	11
Total number of comparisons	16	18	19	18

HWE Hardy–Weinberg Equilibrium, S number of significant associations, A number of non-redundant references that contributed to instability, B number of robust findings
*Significant associations
[31]^a AU; [31]^b SA