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Sports Medicine - Open

Table 4 Summary outcomes of associations in rs71746744, rs16399, and rs3196378 COL5A1 polymorphisms with tendon injury

From: Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Comparison [R] genetic model

Test of association

Test of heterogeneity

n

OR

95% CI

P a

P b

I2 (%)

AM

rs71746744 [25, 27]

 H

3

0.45

0.22–0.95

0.03

0.31

13

FE

 R

3

0.57

0.28–1.17

0.13

0.32

12

FE

 D

3

0.57

0.39–0.83

0.004

0.70

0

FE

 C

3

0.65

0.48–0.87

0.003

0.41

0

FE

rs16399 [25]

 H

2

0.26

0.10–0.69

0.007

0.38

0

FE

 R

2

0.31

0.12–0.81

0.02

0.40

0

FE

 D

2

0.57

0.37–0.88

0.01

0.42

0

FE

 C

2

0.58

0.41–0.82

0.002

0.23

30

FE

rs319378 [27, 31]

 H

3

0.93

0.58–1.49

0.77

0.76

0

FE

 R

3

0.70

0.49–1.01

0.06

0.50

0

FE

 D

3

1.22

0.84–1.77

0.29

0.16

46

FE

 C

3

0.83

0.67–1.02

0.08

0.22

34

FE

  1. Cut-offs for Pa and Pb are < 0.05 and 0.10, respectively. Values in italics indicate significant associations
  2. H homozygous, R recessive, D dominant, C codominant, n number of studies, [R] References, OR odds ratio, CI confidence interval, Pa p value for association, Pb p value for heterogeneity, AM analysis model, FE fixed-effects
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