Skip to main content

Table 4 Summary outcomes of associations in rs71746744, rs16399, and rs3196378 COL5A1 polymorphisms with tendon injury

From: Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Comparison [R] genetic model Test of association Test of heterogeneity
n OR 95% CI P a P b I2 (%) AM
rs71746744 [25, 27]
 H 3 0.45 0.22–0.95 0.03 0.31 13 FE
 R 3 0.57 0.28–1.17 0.13 0.32 12 FE
 D 3 0.57 0.39–0.83 0.004 0.70 0 FE
 C 3 0.65 0.48–0.87 0.003 0.41 0 FE
rs16399 [25]
 H 2 0.26 0.10–0.69 0.007 0.38 0 FE
 R 2 0.31 0.12–0.81 0.02 0.40 0 FE
 D 2 0.57 0.37–0.88 0.01 0.42 0 FE
 C 2 0.58 0.41–0.82 0.002 0.23 30 FE
rs319378 [27, 31]
 H 3 0.93 0.58–1.49 0.77 0.76 0 FE
 R 3 0.70 0.49–1.01 0.06 0.50 0 FE
 D 3 1.22 0.84–1.77 0.29 0.16 46 FE
 C 3 0.83 0.67–1.02 0.08 0.22 34 FE
  1. Cut-offs for Pa and Pb are < 0.05 and 0.10, respectively. Values in italics indicate significant associations
  2. H homozygous, R recessive, D dominant, C codominant, n number of studies, [R] References, OR odds ratio, CI confidence interval, Pa p value for association, Pb p value for heterogeneity, AM analysis model, FE fixed-effects