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Table 3 Post-outlier analysis outcomes of the COL5A1 polymorphism associations with TLI

From: Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Comparison genetic model

n

[R]

Test of association

Test of heterogeneity

Outlier treatment effect

OR

95% CI

P a

P b

I2 (%)

AM

rs12722 all

 R

8

[26, 27, 29, 31, 32]

0.65

0.52–0.81

0.0002

0.19

30

FE

RH, ES

 D

7

[26,27,28,29, 31, 32]

0.72

0.61–0.86

0.0003

0.88

0

FE

EH, GS

 C

8

[26, 28,29,30,31,32]

0.78

0.69–0.87

0.0001

0.63

0

FE

EH, GS

rs13946 all

 H

3

[30, 31]

0.37

0.17–0.82

0.01

0.73

0

FE

EH, GS

 R

3

[30, 31]

0.35

0.16–0.77

0.009

0.86

0

FE

EH, GS

 D

4

[30,31,32]

0.95

0.74–1.22

0.69

0.36

8

FE

RH

 C

4

[30,31,32]

0.90

0.74–1.10

0.30

0.36

6

FE

RH

rs12722 HWE

 R

6

[27, 29,30,31,32]

0.67

0.53–0.86

0.002

0.14

40

FE

RH. GS

 D

6

[27,28,29,30,31,32]

0.76

0.63–0.92

0.004

0.96

0

FE

EH, GS

 C

6

[28,29,30,31,32]

0.76

0.66–0.86

10 −5

0.94

0

FE

EH, GS

rs13946 HWE

 H

3

[31]

0.73

0.38–1.38

0.33

0.16

46

FE

RH

 R

3

[31]

0.77

0.41–1.43

0.40

0.11

55

FE

RH

 D

3

[31]

0.93

0.71–1.24

0.64

0.20

37

FE

RH

 C

3

[31]

0.92

0.74–1.16

0.49

0.23

32

FE

RH

rs12722 tendon

 R

3

[26, 31]

0.45

0.28–0.72

0.0008

0.45

0

FE

EH, GS

 D

4

[26,27,28, 31]

0.66

0.52–0.84

0.0006

0.76

0

FE

EH, GS

 C

4

[26,27,28, 31]

0.78

0.65–0.94

0.008

0.18

38

FE

RH, GS

rs13946 tendon

 H

2

[31]

0.32

0.13–0.79

0.01

0.69

0

FE

EH, GS

 R

2

[31]

0.32

0.13–0.78

0.01

0.79

0

FE

EH, GS

 D

2

[31]

0.85

0.59–1.24

0.40

0.39

0

FE

EH

 C

2

[31]

0.75

0.55–1.02

0.06

0.58

0

FE

EH

rs12722 ligament

 D

3

[29, 30, 32]

0.8

0.62–1.04

0.10

0.97

0

FE

EH

  1. Cut-offs for Pa and Pb are < 0.05 and 0.10, respectively. Values in italics indicate significant associations
  2. H homozygous, R recessive, D dominant, C codominant, n number of studies, [R] References, OR odds ratio, CI confidence interval, Pa p-value for association, Pb p value for heterogeneity, AM analysis model, HWE Hardy–Weinberg Equilibrium, FE fixed-effects, RH reduced heterogeneity, ES elevated significance, EH eliminated heterogeneity, GS gained significance
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