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Table 3 Post-outlier analysis outcomes of the COL5A1 polymorphism associations with TLI

From: Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Comparison genetic model n [R] Test of association Test of heterogeneity Outlier treatment effect
OR 95% CI P a P b I2 (%) AM
rs12722 all
 R 8 [26, 27, 29, 31, 32] 0.65 0.52–0.81 0.0002 0.19 30 FE RH, ES
 D 7 [26,27,28,29, 31, 32] 0.72 0.61–0.86 0.0003 0.88 0 FE EH, GS
 C 8 [26, 28,29,30,31,32] 0.78 0.69–0.87 0.0001 0.63 0 FE EH, GS
rs13946 all
 H 3 [30, 31] 0.37 0.17–0.82 0.01 0.73 0 FE EH, GS
 R 3 [30, 31] 0.35 0.16–0.77 0.009 0.86 0 FE EH, GS
 D 4 [30,31,32] 0.95 0.74–1.22 0.69 0.36 8 FE RH
 C 4 [30,31,32] 0.90 0.74–1.10 0.30 0.36 6 FE RH
rs12722 HWE
 R 6 [27, 29,30,31,32] 0.67 0.53–0.86 0.002 0.14 40 FE RH. GS
 D 6 [27,28,29,30,31,32] 0.76 0.63–0.92 0.004 0.96 0 FE EH, GS
 C 6 [28,29,30,31,32] 0.76 0.66–0.86 10 −5 0.94 0 FE EH, GS
rs13946 HWE
 H 3 [31] 0.73 0.38–1.38 0.33 0.16 46 FE RH
 R 3 [31] 0.77 0.41–1.43 0.40 0.11 55 FE RH
 D 3 [31] 0.93 0.71–1.24 0.64 0.20 37 FE RH
 C 3 [31] 0.92 0.74–1.16 0.49 0.23 32 FE RH
rs12722 tendon
 R 3 [26, 31] 0.45 0.28–0.72 0.0008 0.45 0 FE EH, GS
 D 4 [26,27,28, 31] 0.66 0.52–0.84 0.0006 0.76 0 FE EH, GS
 C 4 [26,27,28, 31] 0.78 0.65–0.94 0.008 0.18 38 FE RH, GS
rs13946 tendon
 H 2 [31] 0.32 0.13–0.79 0.01 0.69 0 FE EH, GS
 R 2 [31] 0.32 0.13–0.78 0.01 0.79 0 FE EH, GS
 D 2 [31] 0.85 0.59–1.24 0.40 0.39 0 FE EH
 C 2 [31] 0.75 0.55–1.02 0.06 0.58 0 FE EH
rs12722 ligament
 D 3 [29, 30, 32] 0.8 0.62–1.04 0.10 0.97 0 FE EH
  1. Cut-offs for Pa and Pb are < 0.05 and 0.10, respectively. Values in italics indicate significant associations
  2. H homozygous, R recessive, D dominant, C codominant, n number of studies, [R] References, OR odds ratio, CI confidence interval, Pa p-value for association, Pb p value for heterogeneity, AM analysis model, HWE Hardy–Weinberg Equilibrium, FE fixed-effects, RH reduced heterogeneity, ES elevated significance, EH eliminated heterogeneity, GS gained significance