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Table 5 Modulation of TLR2 and TLR4 after acute resistance exercise

From: Aerobic but not Resistance Exercise Can Induce Inflammatory Pathways via Toll-Like 2 and 4: a Systematic Review

Authors Sample Disease Intensity and duration Post-exercise results
TLR Cytokine Other
Millard et al. 2013 [123] Adults No disease 120–150 beats/min, 68.8 s (up and down 150 steps) ↔TLR2 ↔IFN-γ ↑CD3−/CD56+NK, ↓NK CD56bright
Short exercise did not affect NK cytotoxicity.
Fernandez-Gonzalo et al. 2012 [88] Adults No disease 40–50 MVIC, 18 acute eccentric bouts ↓TLR4 ↓TNF-α ↓CD14, ↓MyD88, ↓TRIF, ↓TRAF6, ↓p65, ↓phospho-IκB, ↓phospho-ERK1/2, ↓CRP, 2 h after the 2nd acute session.
Fernandez-Gonzalo et al. 2014 [122] Adults No disease 40–50 MVIC, 18 acute eccentric bouts ↓TLR4 ↓TNF-α ↓CD14, ↓MyD88, ↓TRIF, ↓TRAF6, ↓p65, ↓phospho-IκB, ↓phospho-ERK1/2, ↓CRP, 2 h after the 2nd acute session.
McFarlin et al. 2004 [29] Elderly No disease 80% 1 RM, 1 bout/3 sets/10 repetitions ↓TLR4 ↔TNF-α ↔IL-6
↔IL-1β
↔CD14