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Table 1 Comparison of physical characteristics of select NSAIDs to Lipinski’s Rule of 5 [42, 44, 103,104,105]

From: Topical Administration of Ibuprofen for Injured Athletes: Considerations, Formulations, and Comparison to Oral Delivery

 

Lipinski’s Rule of 5

Ibuprofen

Ketoprofen

Diclofenac

Celecoxib

Molecular weight, (Da)

< 500

206

254

296

381

H-bond donors

< 5

1

1

2

1

H-bond acceptors

< 10

2

3

3

7

Log P

< 5

3.97

3.1

4.4

3.4

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