Table 4 Moderator subgroup analysis for TTE

TTE Overall

SMD = 0.08

CI: − 0.21, 0.37

p = 0.58

Sex

Male:

SMD = 0.29

CI: − 0.17, 0.75

p = 0.21

Mixed:

SMD = − 0.06

CI: − 0.43, 0.32

p = 0.76

Health Status

Healthy:

SMD = 0.15

CI: − 0.18, 0.49

p = 0.37

Clinical:

SMD = − 0.13

CI: − 0.71, 0.45

p = 0.66

Oxygen

Normoxia:

SMD = − 0.04

CI: − 0.39, 0.31

p = 0.81

Hypoxia:

SMD = 0.36

CI: − 0.16, 0.88

p = 0.18

Route of Administration

BRJ:

SMD = 0.14

CI: − 0.18, 0.46

p = 0.40

Other:

SMD = − 0.15

CI: − 0.81, 0.50

p = 0.65

Acute Dosing Prior

Yes

SMD = 0.09

CI: − 0.23, 0.41

p = 0.57

No

SMD = 0.03

CI: − 0.65, 0.72

p = 0.93