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Table 2 Diagnostic performance of the LEAF-Q overall score to identify individuals with clinical indicators of the Triad

From: Evaluating the Suitability of the Low Energy Availability in Females Questionnaire (LEAF-Q) for Female Football Players

Measure

AUC [95% CI]

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

RMRRatio (< 0.90)

0.46 [0.31, 0.62]

24

63

26

60

RMRRatio (< 0.90)a

 

14

90

50

66

BMD (Z-score < − 1)

     

 Hipb

 Lumbar spine

0.53 [0.37, 0.68]

0

68

0

98

 Lumbar spinea

 

100

44

3

100

 Hip

0.44 [0.28, 0.61]

0

10

0

5

 Hipa

 

45

100

100

44

 Lumbar spine

0.65 [0.40, 0.91]

40

69

11

93

 Lumbar spinea

 

40

95

40

95

 RMR < 30 kcal/kg−1 FFM/day−1

0.44 [0.29, 0.59]

28

66

37

56

 RMR < 30 kcal/kg−1 FFM.day−1 a

 

12

91

50

59

 Amenorrhea [27]

0.86 [0.69, 1.03]

75

79

60

88

 Amenorrheaa

 

75

95

86

90

  1. Cut-off values are based on consensus values derived in the literature
  2. a = Best performing cut-off value based on Youden’s index, b = indicates that no participant presented with the condition variable, not allowing for statistical analysis
  3. EA = energy availability, LEA = low energy availability, AUC = area under the curve, CI = confidence intervals, RMR = resting metabolic rate, FFM = fat free mass, PPV = positive predictive value, NPV = negative predictive value, BMD = bone mass density