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Table 2 Cardio-pulmonary exercise variables after bisoprolol vs placebo

From: Beta-Adrenergic Receptor Blockade Effects on Cardio-Pulmonary Exercise Testing in Healthy Young Adults: A Randomized, Placebo-Controlled Trial

 

Placebo

2.5 mg

5.0 mg

Ventilatory threshold

HR (b/min)

143 ± 17

119 ± 12***

111 ± 12***$$

SBP (mmHg)

151 ± 16

130 ± 21 ***

117 ± 14 ***$

DBP (mmHg)

73 ± 10

68 ± 8

64 ± 8**

VO2 (L/min)

1.8 ± 0.5

1.7 ± 0.4

1.6 ± 0.4

VE/VCO2 ratio

28 ± 3

28 ± 4

28 ± 4

Maximal exercise

RER

1.29 ± 0.09

1.27 ± 0.07

1.30 ± 0.08

HR (b/min)

183 ± 8

160 ± 11***

151 ± 12***$$

Chronotropic Index

0.87 ± 0.06

0.71 ± 0.08***

0.65 ± 0.08***$$

SBP (mmHg)

196 ± 20

179 ± 23 **

160 ± 22 ***$$

DBP (mmHg)

81 ± 13

78 ± 14

73 ± 11*

Workload (Watt)

246 ± 48

245 ± 52

238 ± 42

VO2 (L/min)

2.7 ± 0.5

2.7 ± 0.5

2.6 ± 0.5

VO2 (mL/kg/min)

39 ± 5

39 ± 5

37 ± 5

O2 Pulse (mL/b/min)

15.0 ± 3.2

17.1 ± 3.7*

17.3 ± 3.7*

VE (L/min)

114 ± 16

105 ± 16

104 ± 21

VE/MVV (%)

78 ± 9

74 ± 9

74 ± 12

SpO2 (%)

98 ± 2

98 ± 2

98 ± 2

Slopes

VE/VCO2

27 ± 3

26 ± 3

26 ± 4

HR/VO2 (b/mL/kg)

2.9 ± 0.4

2.4 ± 0.5***

2.3 ± 0.4***

VO2/W (mL/min/watt)

10 ± 1

10 ± 1

10 ± 1

Recovery

HRR 1' (b/min)

26 ± 7

32 ± 6**

33 ± 6**

HRR 2' (b/min)

45 ± 7

48 ± 6

46 ± 7

  1. RER: Respiratory Exchange Ratio; HR: Heart Rate; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; VO2: Oxygen consumption; VE: Ventilation; MVV: Maximal Voluntary Ventilation; HRR: Heart Rate Recovery
  2. *p < 0.05, **p < 0.01, ***p < 0.001 both measurements vs placebo; $$p < 0.01 comparison 2.5 vs 5.0 mg bisoprolol