Gene | Genotype | Muscle | Tendon | Ligament | Bone | ||||
---|---|---|---|---|---|---|---|---|---|
Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | ||
All injuries | |||||||||
COL5A1 | CC | 4.57 | [− 0.08 to 9.22] | 2.14 | [− 0.70 to 4.99] | 6.57 | [0.90 to 12.24] | 1.57 | [− 0.27 to 3.41] |
(rs12722) | CT | 6.96 | [5.15 to 8.76] | 1.48 | [0.77 to 2.19] | 8.09 | [4.25 to 1.92] | 2.78 | [1.56 to 4.01] |
 | TT | 7.40 | [3.76 to 11.13] | 1.40 | [0.54 to 2.26] | 6.53 | [2.37 to 10.69] | 2.47 | [1.36 to 3.57] |
NOGGIN | GG | 7.29 | [2.67 to 11.90] | 2.71 | [− 0.10 to 5.53] | 7.71 | [1.03 to 14.40] | 3.00 | [1.00 to 5.00] |
(rs1372857) | AG | 7.73 | [5.25 to 10.20] | 1.27 | [0.78 to 1.77] | 6.73 | [4.03 to 9.43] | 2.82 | [1.64 to 3.99] |
 | AA | 5.13 | [2.59 to 7.66] | 1.44 | [0.37 to 2.50] | 8.00 | [2.39 to 13.61] | 1.81 | [0.61 to 3.02] |
COL1A1 | TT | 7.00 | [5.27 to 8.73] | 1.59 | [0.92 to 2.27] | 8.72 | [5.51 to 11.93] | 2.69 | [1.77 to 3.60] |
(rs1800012) | GT | 6.08 | 2.24 to 9.92] | 1.46 | [0.29 to 2.63] | 3.92 | [2.12 to 5.73] | 2.00 | [0.65 to 3.35] |
 | GG | – | – | – | – | – | – | – | – |
ACTN3 | CC | 8.15 | [5.68 to 10.62] | 1.95 | [0.82 to 3.08] | 8.45 | [5.33 to 11.57] | 2.85 | [1.86 to 3.84] |
(rs1815739) | CT | 6.00 | [3.82 to 8.18] | 1.30 | [0.76 to 1.85] | 6.96 | [3.04 to 10.87] | 2.26 | [1.05 to 3.47] |
 | TT | 1.00 | [1.00 to 1.00] | 0.50 | [− 5.85 to 6.85] | 0.50 | [− 5.85 to 6.85] | 1.50 | [− 4.85 to 7.85] |
SMAD6 | CC | 7.57 | [0.63 to 14.51] | 1.57 | 0.39 to 2.75] | 4.14 | [1.30 to 6.99] | 3.57 | [0.70 to 6.44] |
(rs2053423) | CT | 6.13 | [3.68 to 8.59] | 2.20 | [0.73 to 3.67] | 11.00 | [5.31 to 16.69] | 3.13 | [1.99 to 4.28] |
 | TT | 6.87 | [4.64 to 9.10] | 1.13 | [0.59 to 1.67] | 5.91 | [3.12 to 8.71] | 1.74 | [0.74 to 2.74] |
EMILIN1 | GG | 6.70 | [4.19 to 9.21] | 1.80 | [0.91 to 2.69] | 8.60 | [5.09 to 12.11] | 2.55 | [1.28 to 3.82] |
(rs2289360) | AG | 6.60 | [4.19 to 9.01] | 1.40 | [0.15 to 2.65] | 6.53 | [1.03 to 12.04] | 2.47 | [1.16 to 3.77] |
 | AA | 7.00 | [2.25 to 11.75] | 1.30 | [0.54 to 2.06] | 6.00 | [2.14 to 9.86] | 2.40 | [0.78 to 4.02] |
CCL2 | CC | 0.00 | [0.00 to 0.00] | 0.00 | [0.00 to 0.00] | 1.00 | [− 11.71 to 13.71] | 3.00 | [3.00 to 3.00] |
(rs2857656) | CG | 7.48 | [5.22 to 9.73] | 1.96 | [0.96 to 2.95] | 9.17 | [4.95 to 13.40] | 3.00 | [1.81 to 4.19] |
 | GG | 6.55 | [4.13 to 8.97] | 1.25 | [0.71 to 1.79] | 5.85 | [3.53 to 8.17] | 1.85 | [0.87 to 2.83] |
IGF2 | CC | 5.00 | [0.96 to 9.04] | 0.83 | [− 0.39 to 2.06] | 5.33 | [1.15 to 9.51] | 1.17 | [− 0.06 to 2.39] |
(rs3213221) | GC | 8.88 | [6.54 to 11.21] | 2.04 | [1.07 to 3.02] | 9.58 | [5.54 to 13.62] | 3.04 | [2.18 to 3.90] |
 | GG | 4.00 | [1.96 to 6.04] | 1.07 | [0.58 to 1.56] | 4.53 | [1.86 to 7.20] | 2.13 | [0.37 to 3.90] |
COL12A1 | GG | – | – | – | – | – | – | – | – |
(rs970547) | AG | 7.31 | [3.33 to 11.28] | 1.15 | [0.42 to 1.89] | 9.92 | [2.91 to 16.93] | 3.38 | [2.24 to 4.53] |
 | AA | 6.23 | [4.57 to 7.88] | 1.74 | [0.97 to 2.51] | 6.19 | [4.05 to 8.34] | 2.10 | [1.14 to 3.05] |
Non-Contact Injuries | |||||||||
COL5A1 | CC | 4.14 | [− 0.14 to 8.43] | 1.86 | [− 0.73 to 4.44] | 1.00 | [− 0.41 to 2.41] | 1.00 | [− 0.41 to 2.41] |
(rs12722) | CT | 6.04 | [4.58 to 7.50] | 1.30 | [0.71 to 1.89] | 1.65 | [0.86 to 2.44] | 1.87 | [0.72 to 3.02] |
 | TT | 6.00 | [2.76 to 9.24] | 1.13 | [0.35 to 1.91] | 1.80 | [0.67 to 2.93] | 0.93 | [0.36 to 1.51] |
NOGGIN | GG | 6.43 | [2.62 to 10.24] | 2.43 | − 0.01 to 4.87] | 1.86 | [− 0.50 to 4.21] | 1.86 | [− 0.44 to 4.15] |
(rs1372857) | AG | 6.50 | [4.28 to 8.72] | 1.00 | [0.61 to 1.39] | 1.50 | [0.83 to 2.17] | 1.55 | [0.46 to 2.63] |
 | AA | 4.38 | [2.41 to 6.34] | 1.31 | [0.35 to 2.28] | 1.63 | [0.54 to 2.71] | 1.06 | [0.35 to 1.78] |
COL1A1 | TT | 5.91 | [4.43 to 7.38] | 1.38 | [0.78 to 1.97] | 2.06 | [1.35 to 2.77] | 1.59 | [0.84 to 2.35] |
(rs1800012) | GT | 5.31 | [2.01 to 8.60] | 1.23 | [0.21 to 2.25] | 0.46 | [0.06 to 0.86] | 1.00 | [− 0.28 to 2.28] |
 | GG | – | – | – | – | – | – | – | – |
ACTN3 | CC | 7.20 | [4.96 to 9.44] | 1.55 | [0.60 to 2.50] | 2.10 | [1.19 to 3.01] | 1.90 | [0.95 to 2.85] |
(rs1815739) | CT | 4.91 | [3.24 to 6.59] | 1.22 | [0.66 to 1.77] | 1.30 | [0.56 to 2.05] | 1.13 | [0.19 to 2.07] |
 | TT | 0.50 | [− 5.85 to 6.85] | 0.50 | [− 5.85 to 6.85] | 0.00 | [0.00 to 0.00] | 0.00 | [0.00 to 0.00] |
SMAD6 | CC | 7.00 | 0.73 to 13.27] | 1.43 | [0.38 to 2.48] | 0.86 | [0.22 to 1.50] | 2.29 | [− 1.04 to 5.61] |
(rs2053423) | CT | 5.20 | [3.13 to 7.27] | 1.87 | [0.58 to 3.15] | 2.20 | [1.03 to 3.37] | 1.67 | [0.84 to 2.50] |
 | TT | 5.70 | [3.87 to 7.52] | 0.96 | [0.48 to 1.44] | 1.43 | [0.64 to 2.23] | 1.00 | [0.21 to 1.79] |
EMILIN1 | GG | 5.60 | [3.43 to 7.77] | 1.35 | [0.57 to 2.13] | 2.00 | [1.03 to 2.97] | 1.50 | [0.37 to 2.63] |
(rs2289360) | AG | 5.60 | [3.75 to 7.45] | 1.40 | [0.30 to 2.50] | 1.07 | [0.17 to 1.97] | 1.67 | [0.49 to 2.84] |
 | AA | 6.20 | [1.99 to 10.41] | 1.20 | [0.46 to 1.94] | 1.60 | [0.47 to 2.73 | 0.90 | [− 0.02 to 1.82] |
CCL2 | CC | 0.00 | [0.00 to 0.00] | 0.00 | [0.00 – 0.00] | 0.00 | [0.00 to 0.00] | 0.50 | [− 5.85 to 6.85] |
(rs2857656) | CG | 6.48 | [4.54 to 8.41] | 1.74 | [0.86 to 2.62] | 1.87 | [0.88 to 2.86] | 2.04 | [0.96 to 3.13] |
 | GG | 5.45 | [3.42 to 7.48] | 1.00 | [0.54 to 1.46] | 1.45 | [0.89 to 2.01] | 0.80 | [0.16 to 1.44] |
IGF2 | CC | 4.17 | [1.02 to 7.31] | 0.50 | [− 0.38 to 1.38] | 1.50 | [0.40 to 2.60] | 0.67 | [− 0.60 to 1.94] |
(rs3213221) | GC | 7.50 | [5.46 to 9.54] | 1.67 | [0.80 to 2.54] | 2.08 | [1.16 to 3.01] | 1.54 | [0.81 to 2.28] |
 | GG | 3.53 | [1.81 to 5.26] | 1.13 | [0.67 to 1.60] | 0.87 | [0.21 to 1.52] | 1.53 | [− 0.03 to 3.10] |
COL12A1 | GG | – | – | – | – | – | – | – | – |
(rs970547) | AG | 6.31 | [2.78 to 9.83] | 0.92 | [0.46 to 1.38] | 1.85 | [0.41 to 3.28] | 2.15 | [0.92 to 3.38] |
 | AA | 5.23 | [3.90 to 6.55] | 1.52 | [0.82 to 2.21] | 1.52 | [0.92 to 2.11] | 1.13 | [0.36 to 1.90] |
Contact injuries | |||||||||
COL5A1 | CC | 0.29 | [− 0.17 to 0.74] | 0.29 | [− 0.17 to 0.74] | 5.14 | [1.28 to 9.01] | 0.57 | [− 0.33 to 1.47] |
(rs12722) | CT | 0.61 | [0.20 to 1.02] | 0.13 | [− 0.02 to 0.28] | 4.61 | [3.00 to 6.22] | 0.65 | [0.23 to 1.08] |
 | TT | 0.33 | [− 0.01 to 0.68] | 0.20 | [− 0.03 to 0.43] | 4.07 | [1.29 to 6.85] | 1.27 | [0.47 to 2.06] |
NOGGIN | GG | 0.43 | [− 0.07 to 0.92] | 0.29 | [− 0.17 to 0.74] | 5.29 | [1.48 to 9.09] | 1.14 | [0.02 to 2.27] |
(rs1372857) | AG | 0.55 | [0.25 to 0.84] | 0.23 | [0.04 to 0.42] | 4.32 | [2.49 to 6.15] | 0.91 | [0.46 to 1.36] |
 | AA | 0.38 | [− 0.17 to 0.92] | 0.06 | [− 0.07 to 0.20] | 4.44 | [2.04 to 6.84] | 0.65 | [− 0.10 to 1.35] |
COL1A1 | TT | 0.59 | [0.28 to 0.91] | 0.22 | [0.07 to 0.37] | 5.09 | [3.42 to 6.77] | 0.94 | [0.49 to 1.39] |
(rs1800012) | GT | 0.15 | [− 0.07 to 0.38] | 0.08 | [− 0.09 to 0.24] | 3.08 | [1.67 to 4.48] | 0.62 | [0.03 to 1.20] |
 | GG | – | – | – | – | – | – | – | – |
ACTN3 | CC | 0.45 | [0.13 to 0.77] | 0.25 | [0.04 to 0.46] | 5.45 | [3.43 to 7.47] | 0.80 | [0.35 to 1.25] |
(rs1815739) | CT | 0.52 | [0.13 to 0.91] | 0.13 | [− 0.02 to 0.28] | 4.09 | [2.35 to 5.82] | 0.87 | [0.27 to 1.47] |
 | TT | 0.00 | [0.00 to 0.00] | 0.00 | [0.00 to 0.00] | 0.00 | [0.00 to 0.00] | 1.00 | [1.00 to 1.00] |
SMAD6 | CC | 0.29 | [− 0.17 to 0.74] | 0.00 | [0.00 to 0.00] | 2.86 | [0.69 to 5.02] | 0.86 | [− 0.27 to 1.98] |
(rs2053423) | CT | 0.53 | [0.18 to 0.89] | 0.27 | [0.01 to 0.52] | 6.20 | [3.77 to 8.63] | 1.13 | [0.51 to 1.76] |
 | TT | 0.48 | [0.07 to 0.89] | 0.17 | [0.01 to 0.34] | 3.91 | [2.08 to 5.75] | 0.65 | [0.14 to 1.17] |
EMILIN1 | GG | 0.50 | [0.18 to 0.82] | 030 | [0.08 to 0.52] | 5.40 | [3.15 to 7.65] | 0.85 | [0.26 to 1.44] |
(rs2289360) | AG | 0.33 | [0.06 to 0.60] | 0.07 | [− 0.08 to 0.21] | 3.80 | [1.88 to 5.72] | 0.60 | [0.14 to 1.06] |
 | AA | 0.60 | [− 0.30 to 1.50] | 0.10 | [− 0.13 to 0.33] | 3.80 | [1.04 to 6.56] | 1.20 | [0.20 to 2.20] |
CCL2 | CC | 0.00 | [0.00 to 0.00] | 0.00 | [0.00 – 0.00] | 0.50 | [− 5.85 to 6.85] | 1.00 | [− 11.71 to 13.71] |
(rs2857656) | CG | 0.48 | [0.09 to 0.87] | 0.17 | [0.01 to 0.34] | 5.52 | [3.51 to 7.53] | 0.78 | [0.26 to 1.30] |
 | GG | 0.50 | [0.18 to 0.82] | 0.20 | [0.01 to 0.39] | 3.75 | [2.14 to 5.36] | 0.90 | [0.35 to 1.45] |
IGF2 | CC | 0.50 | [− 0.38 to 1.38] | 0.33 | [− 0.21 to 0.88] | 3.50 | [0.55 to 6.45] | 0.50 | [− 0.38 to 1.38] |
(rs3213221) | GC | 0.63 | [0.23 to 1.02] | 0.25 | [0.06 to 0.44] | 5.67 | [3.71 to 7.62] | 1.29 | [0.76 to 1.83] |
 | GG | 0.20 | [− 0.03 to 0.43] | 0.00 | [0.00 to 0.00] | 3.07 | [1.15 to 4.98] | 0.27 | [− 0.18 to 0.71] |
COL12A1 | GG | – | – | – | – | – | – | – | – |
(rs970547) | AG | 0.46 | [0.06 to 0.86] | 0.08 | [− 0.09 to 0.24] | 5.54 | [2.53 to 8.55] | 0.85 | [0.25 to 1.44] |
 | AA | 0.45 | [0.14 to 0.76] | 0.23 | [0.07 to 0.38] | 4.00 | [2.59 to 5.41] | 0.81 | [0.35 to 1.26] |