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Table 3 Mean number of total muscle and tendon, ligament, and bone injuries when categorised by candidate variant genotype

From: Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study

Gene

Genotype

Muscle

Tendon

Ligament

Bone

Mean

95% CI

Mean

95% CI

Mean

95% CI

Mean

95% CI

All injuries

COL5A1

CC

4.57

[− 0.08 to 9.22]

2.14

[− 0.70 to 4.99]

6.57

[0.90 to 12.24]

1.57

[− 0.27 to 3.41]

(rs12722)

CT

6.96

[5.15 to 8.76]

1.48

[0.77 to 2.19]

8.09

[4.25 to 1.92]

2.78

[1.56 to 4.01]

 

TT

7.40

[3.76 to 11.13]

1.40

[0.54 to 2.26]

6.53

[2.37 to 10.69]

2.47

[1.36 to 3.57]

NOGGIN

GG

7.29

[2.67 to 11.90]

2.71

[− 0.10 to 5.53]

7.71

[1.03 to 14.40]

3.00

[1.00 to 5.00]

(rs1372857)

AG

7.73

[5.25 to 10.20]

1.27

[0.78 to 1.77]

6.73

[4.03 to 9.43]

2.82

[1.64 to 3.99]

 

AA

5.13

[2.59 to 7.66]

1.44

[0.37 to 2.50]

8.00

[2.39 to 13.61]

1.81

[0.61 to 3.02]

COL1A1

TT

7.00

[5.27 to 8.73]

1.59

[0.92 to 2.27]

8.72

[5.51 to 11.93]

2.69

[1.77 to 3.60]

(rs1800012)

GT

6.08

2.24 to 9.92]

1.46

[0.29 to 2.63]

3.92

[2.12 to 5.73]

2.00

[0.65 to 3.35]

 

GG

–

–

–

–

–

–

–

–

ACTN3

CC

8.15

[5.68 to 10.62]

1.95

[0.82 to 3.08]

8.45

[5.33 to 11.57]

2.85

[1.86 to 3.84]

(rs1815739)

CT

6.00

[3.82 to 8.18]

1.30

[0.76 to 1.85]

6.96

[3.04 to 10.87]

2.26

[1.05 to 3.47]

 

TT

1.00

[1.00 to 1.00]

0.50

[− 5.85 to 6.85]

0.50

[− 5.85 to 6.85]

1.50

[− 4.85 to 7.85]

SMAD6

CC

7.57

[0.63 to 14.51]

1.57

0.39 to 2.75]

4.14

[1.30 to 6.99]

3.57

[0.70 to 6.44]

(rs2053423)

CT

6.13

[3.68 to 8.59]

2.20

[0.73 to 3.67]

11.00

[5.31 to 16.69]

3.13

[1.99 to 4.28]

 

TT

6.87

[4.64 to 9.10]

1.13

[0.59 to 1.67]

5.91

[3.12 to 8.71]

1.74

[0.74 to 2.74]

EMILIN1

GG

6.70

[4.19 to 9.21]

1.80

[0.91 to 2.69]

8.60

[5.09 to 12.11]

2.55

[1.28 to 3.82]

(rs2289360)

AG

6.60

[4.19 to 9.01]

1.40

[0.15 to 2.65]

6.53

[1.03 to 12.04]

2.47

[1.16 to 3.77]

 

AA

7.00

[2.25 to 11.75]

1.30

[0.54 to 2.06]

6.00

[2.14 to 9.86]

2.40

[0.78 to 4.02]

CCL2

CC

0.00

[0.00 to 0.00]

0.00

[0.00 to 0.00]

1.00

[− 11.71 to 13.71]

3.00

[3.00 to 3.00]

(rs2857656)

CG

7.48

[5.22 to 9.73]

1.96

[0.96 to 2.95]

9.17

[4.95 to 13.40]

3.00

[1.81 to 4.19]

 

GG

6.55

[4.13 to 8.97]

1.25

[0.71 to 1.79]

5.85

[3.53 to 8.17]

1.85

[0.87 to 2.83]

IGF2

CC

5.00

[0.96 to 9.04]

0.83

[− 0.39 to 2.06]

5.33

[1.15 to 9.51]

1.17

[− 0.06 to 2.39]

(rs3213221)

GC

8.88

[6.54 to 11.21]

2.04

[1.07 to 3.02]

9.58

[5.54 to 13.62]

3.04

[2.18 to 3.90]

 

GG

4.00

[1.96 to 6.04]

1.07

[0.58 to 1.56]

4.53

[1.86 to 7.20]

2.13

[0.37 to 3.90]

COL12A1

GG

–

–

–

–

–

–

–

–

(rs970547)

AG

7.31

[3.33 to 11.28]

1.15

[0.42 to 1.89]

9.92

[2.91 to 16.93]

3.38

[2.24 to 4.53]

 

AA

6.23

[4.57 to 7.88]

1.74

[0.97 to 2.51]

6.19

[4.05 to 8.34]

2.10

[1.14 to 3.05]

Non-Contact Injuries

COL5A1

CC

4.14

[− 0.14 to 8.43]

1.86

[− 0.73 to 4.44]

1.00

[− 0.41 to 2.41]

1.00

[− 0.41 to 2.41]

(rs12722)

CT

6.04

[4.58 to 7.50]

1.30

[0.71 to 1.89]

1.65

[0.86 to 2.44]

1.87

[0.72 to 3.02]

 

TT

6.00

[2.76 to 9.24]

1.13

[0.35 to 1.91]

1.80

[0.67 to 2.93]

0.93

[0.36 to 1.51]

NOGGIN

GG

6.43

[2.62 to 10.24]

2.43

− 0.01 to 4.87]

1.86

[− 0.50 to 4.21]

1.86

[− 0.44 to 4.15]

(rs1372857)

AG

6.50

[4.28 to 8.72]

1.00

[0.61 to 1.39]

1.50

[0.83 to 2.17]

1.55

[0.46 to 2.63]

 

AA

4.38

[2.41 to 6.34]

1.31

[0.35 to 2.28]

1.63

[0.54 to 2.71]

1.06

[0.35 to 1.78]

COL1A1

TT

5.91

[4.43 to 7.38]

1.38

[0.78 to 1.97]

2.06

[1.35 to 2.77]

1.59

[0.84 to 2.35]

(rs1800012)

GT

5.31

[2.01 to 8.60]

1.23

[0.21 to 2.25]

0.46

[0.06 to 0.86]

1.00

[− 0.28 to 2.28]

 

GG

–

–

–

–

–

–

–

–

ACTN3

CC

7.20

[4.96 to 9.44]

1.55

[0.60 to 2.50]

2.10

[1.19 to 3.01]

1.90

[0.95 to 2.85]

(rs1815739)

CT

4.91

[3.24 to 6.59]

1.22

[0.66 to 1.77]

1.30

[0.56 to 2.05]

1.13

[0.19 to 2.07]

 

TT

0.50

[− 5.85 to 6.85]

0.50

[− 5.85 to 6.85]

0.00

[0.00 to 0.00]

0.00

[0.00 to 0.00]

SMAD6

CC

7.00

0.73 to 13.27]

1.43

[0.38 to 2.48]

0.86

[0.22 to 1.50]

2.29

[− 1.04 to 5.61]

(rs2053423)

CT

5.20

[3.13 to 7.27]

1.87

[0.58 to 3.15]

2.20

[1.03 to 3.37]

1.67

[0.84 to 2.50]

 

TT

5.70

[3.87 to 7.52]

0.96

[0.48 to 1.44]

1.43

[0.64 to 2.23]

1.00

[0.21 to 1.79]

EMILIN1

GG

5.60

[3.43 to 7.77]

1.35

[0.57 to 2.13]

2.00

[1.03 to 2.97]

1.50

[0.37 to 2.63]

(rs2289360)

AG

5.60

[3.75 to 7.45]

1.40

[0.30 to 2.50]

1.07

[0.17 to 1.97]

1.67

[0.49 to 2.84]

 

AA

6.20

[1.99 to 10.41]

1.20

[0.46 to 1.94]

1.60

[0.47 to 2.73

0.90

[− 0.02 to 1.82]

CCL2

CC

0.00

[0.00 to 0.00]

0.00

[0.00 – 0.00]

0.00

[0.00 to 0.00]

0.50

[− 5.85 to 6.85]

(rs2857656)

CG

6.48

[4.54 to 8.41]

1.74

[0.86 to 2.62]

1.87

[0.88 to 2.86]

2.04

[0.96 to 3.13]

 

GG

5.45

[3.42 to 7.48]

1.00

[0.54 to 1.46]

1.45

[0.89 to 2.01]

0.80

[0.16 to 1.44]

IGF2

CC

4.17

[1.02 to 7.31]

0.50

[− 0.38 to 1.38]

1.50

[0.40 to 2.60]

0.67

[− 0.60 to 1.94]

(rs3213221)

GC

7.50

[5.46 to 9.54]

1.67

[0.80 to 2.54]

2.08

[1.16 to 3.01]

1.54

[0.81 to 2.28]

 

GG

3.53

[1.81 to 5.26]

1.13

[0.67 to 1.60]

0.87

[0.21 to 1.52]

1.53

[− 0.03 to 3.10]

COL12A1

GG

–

–

–

–

–

–

–

–

(rs970547)

AG

6.31

[2.78 to 9.83]

0.92

[0.46 to 1.38]

1.85

[0.41 to 3.28]

2.15

[0.92 to 3.38]

 

AA

5.23

[3.90 to 6.55]

1.52

[0.82 to 2.21]

1.52

[0.92 to 2.11]

1.13

[0.36 to 1.90]

Contact injuries

COL5A1

CC

0.29

[− 0.17 to 0.74]

0.29

[− 0.17 to 0.74]

5.14

[1.28 to 9.01]

0.57

[− 0.33 to 1.47]

(rs12722)

CT

0.61

[0.20 to 1.02]

0.13

[− 0.02 to 0.28]

4.61

[3.00 to 6.22]

0.65

[0.23 to 1.08]

 

TT

0.33

[− 0.01 to 0.68]

0.20

[− 0.03 to 0.43]

4.07

[1.29 to 6.85]

1.27

[0.47 to 2.06]

NOGGIN

GG

0.43

[− 0.07 to 0.92]

0.29

[− 0.17 to 0.74]

5.29

[1.48 to 9.09]

1.14

[0.02 to 2.27]

(rs1372857)

AG

0.55

[0.25 to 0.84]

0.23

[0.04 to 0.42]

4.32

[2.49 to 6.15]

0.91

[0.46 to 1.36]

 

AA

0.38

[− 0.17 to 0.92]

0.06

[− 0.07 to 0.20]

4.44

[2.04 to 6.84]

0.65

[− 0.10 to 1.35]

COL1A1

TT

0.59

[0.28 to 0.91]

0.22

[0.07 to 0.37]

5.09

[3.42 to 6.77]

0.94

[0.49 to 1.39]

(rs1800012)

GT

0.15

[− 0.07 to 0.38]

0.08

[− 0.09 to 0.24]

3.08

[1.67 to 4.48]

0.62

[0.03 to 1.20]

 

GG

–

–

–

–

–

–

–

–

ACTN3

CC

0.45

[0.13 to 0.77]

0.25

[0.04 to 0.46]

5.45

[3.43 to 7.47]

0.80

[0.35 to 1.25]

(rs1815739)

CT

0.52

[0.13 to 0.91]

0.13

[− 0.02 to 0.28]

4.09

[2.35 to 5.82]

0.87

[0.27 to 1.47]

 

TT

0.00

[0.00 to 0.00]

0.00

[0.00 to 0.00]

0.00

[0.00 to 0.00]

1.00

[1.00 to 1.00]

SMAD6

CC

0.29

[− 0.17 to 0.74]

0.00

[0.00 to 0.00]

2.86

[0.69 to 5.02]

0.86

[− 0.27 to 1.98]

(rs2053423)

CT

0.53

[0.18 to 0.89]

0.27

[0.01 to 0.52]

6.20

[3.77 to 8.63]

1.13

[0.51 to 1.76]

 

TT

0.48

[0.07 to 0.89]

0.17

[0.01 to 0.34]

3.91

[2.08 to 5.75]

0.65

[0.14 to 1.17]

EMILIN1

GG

0.50

[0.18 to 0.82]

030

[0.08 to 0.52]

5.40

[3.15 to 7.65]

0.85

[0.26 to 1.44]

(rs2289360)

AG

0.33

[0.06 to 0.60]

0.07

[− 0.08 to 0.21]

3.80

[1.88 to 5.72]

0.60

[0.14 to 1.06]

 

AA

0.60

[− 0.30 to 1.50]

0.10

[− 0.13 to 0.33]

3.80

[1.04 to 6.56]

1.20

[0.20 to 2.20]

CCL2

CC

0.00

[0.00 to 0.00]

0.00

[0.00 – 0.00]

0.50

[− 5.85 to 6.85]

1.00

[− 11.71 to 13.71]

(rs2857656)

CG

0.48

[0.09 to 0.87]

0.17

[0.01 to 0.34]

5.52

[3.51 to 7.53]

0.78

[0.26 to 1.30]

 

GG

0.50

[0.18 to 0.82]

0.20

[0.01 to 0.39]

3.75

[2.14 to 5.36]

0.90

[0.35 to 1.45]

IGF2

CC

0.50

[− 0.38 to 1.38]

0.33

[− 0.21 to 0.88]

3.50

[0.55 to 6.45]

0.50

[− 0.38 to 1.38]

(rs3213221)

GC

0.63

[0.23 to 1.02]

0.25

[0.06 to 0.44]

5.67

[3.71 to 7.62]

1.29

[0.76 to 1.83]

 

GG

0.20

[− 0.03 to 0.43]

0.00

[0.00 to 0.00]

3.07

[1.15 to 4.98]

0.27

[− 0.18 to 0.71]

COL12A1

GG

–

–

–

–

–

–

–

–

(rs970547)

AG

0.46

[0.06 to 0.86]

0.08

[− 0.09 to 0.24]

5.54

[2.53 to 8.55]

0.85

[0.25 to 1.44]

 

AA

0.45

[0.14 to 0.76]

0.23

[0.07 to 0.38]

4.00

[2.59 to 5.41]

0.81

[0.35 to 1.26]