Differential Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Sensitivity and Glucose Homeostasis: A Narrative Review

Sports Medicine - Open

Table 1 Exercise intervention groups in the STRRIDE trials

Study and intervention group	n	Exercise prescription
STRRIDE I
High Amount/Vigorous Intensity	64	23 KKW	65–80% peak V̇O₂
Low Amount/Vigorous Intensity	58	14 KKW	65–80% peak V̇O₂
Low Amount/Moderate Intensity	57	14 KKW	40–55% peak V̇O₂
STRRIDE AT/RT
Aerobic Training (Low Amount/Vigorous Intensity)	47	14 KKW	65–80% peak V̇O₂
Resistance Training	51	3 days/week, 3 sets/day, 8–12 reps of 8 exercises
Aerobic + Resistance Training	44	14 KKW at 65–80% peak V̇O₂ + 3 days/week, 3 sets/day, 8–12 reps of 8 exercises
STRRIDE-PD
High Amount/Vigorous Intensity	38	16 KKW	65–80% V̇O₂ reserve
High Amount/Moderate Intensity	40	16 KKW	40–55% V̇O₂ reserve
Low Amount/Moderate Intensity	35	10 KKW	40–55% V̇O₂ reserve
Clinical Lifestyle Intervention	37	10 KKW at 40–55% V̇O₂ reserve + caloric restriction to reduce body weight by 7%

KKW, kcal exercise energy expenditure/kilogram of body weight/week; 23 KKW, calorically equivalent of walking/jogging approximately 20 miles/week for a 90 kg person; 14 KKW, calorically equivalent of walking/jogging approximately 12 miles/week for a 90 kg person; 16 KKW, calorically equivalent of walking/jogging approximately 13.8 miles/week for a 90 kg person; 10 KKW, calorically equivalent of walking/jogging approximately 8.6 miles/week for a 90 kg person