Table 2 The associations between VO2peak normalized for lean mass, and the circulating proteins: sex- and multivariable adjusted linear regression. Only proteins that met the Bonferroni adjusted threshold (p<0.0006) in the primary sex adjusted analyses are presented. Proteins that met p<0.05 threshold in the multivariable-adjusted analyses are highlighted in bold

Fatty acid-binding protein 4 (FABP4)

−.41

−.49

−.32

<0.0001

−.17

−.25

−.09

<0.0001

Interleukin-6 (IL-6)

−.34

−.43

−.25

<0.0001

−.21

−.31

−.10

0.00015

Leptin

−.36

−.43

−.29

<0.0001

−.09

−.15

−.04

0.001

Galanin

.25

.16

.35

<0.0001

.18

.07

.29

0.002

Cystatin-B (CSTB)

−.31

−.40

−.21

<0.0001

−.16

−.27

−.05

0.0046

Interleukin-1 receptor antagonist protein (IL-1RA)

−.39

−.48

−.30

<0.0001

−.13

−.23

−.03

0.0085

Kallikrein-6 (KLK6)

.18

.08

.27

0.0003

.15

.03

.26

0.012

Heparin-binding EGF-like growth factor (HB-EGF)

.18

.08

.28

0.00029

.12

.01

.24

0.037

Growth/differentiation factor 15 (GDF-15)

−.19

−.29

−.09

0.00013

−.11

−.23

.00

0.049

Tissue-type plasminogen activator (t-PA)

−.33

−.42

−.24

<0.0001

−.10

−.19

.00

0.054

Cathepsin D (CTSD)

−.26

−.35

−.17

<0.0001

−.04

−.14

.06

0.46

Hepatocyte growth factor (HGF)

−.25

−.35

−.16

<0.0001

−.02

−.13

.08

0.67

E-selectin (SELE)

−.23

−.33

−.14

<0.0001

−.07

−.18

.04

0.20

Stem cell factor (SCF)

.23

.13

.32

<0.0001

.10

−.01

.22

0.073

Vascular endothelial growth factor D (VEGF-D)

.18

.09

.27

<0.0001

.06

−.04

.16

0.26

Follistatin (FS)

−.19

−.29

−.09

0.00012

−.07

−.18

.05

0.25

Fibroblast growth factor 23 (FGF-23)

−.17

−.27

−.08

0.0004

−.10

−.21

.01

0.084

Tumor necrosis factor ligand superfamily member 14 (TNFSF14)

−.17

−.27

−.07

0.00057

.04

−.07

.15

0.47