Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study

Sports Medicine - Open

Table 2 The associations between VO2peak normalized for lean mass, and the circulating proteins: sex- and multivariable adjusted linear regression. Only proteins that met the Bonferroni adjusted threshold (p<0.0006) in the primary sex adjusted analyses are presented. Proteins that met p<0.05 threshold in the multivariable-adjusted analyses are highlighted in bold

Protein	Sex-adjusted				Multivariable-adjusted^†
	beta	95% CI	95% CI	p-value	beta	95% CI	95% CI	p-value
		low	high			low	high
Fatty acid-binding protein 4 (FABP4)	−.41	−.49	−.32	<0.0001	−.17	−.25	−.09	<0.0001
Interleukin-6 (IL-6)	−.34	−.43	−.25	<0.0001	−.21	−.31	−.10	0.00015
Leptin	−.36	−.43	−.29	<0.0001	−.09	−.15	−.04	0.001
Galanin	.25	.16	.35	<0.0001	.18	.07	.29	0.002
Cystatin-B (CSTB)	−.31	−.40	−.21	<0.0001	−.16	−.27	−.05	0.0046
Interleukin-1 receptor antagonist protein (IL-1RA)	−.39	−.48	−.30	<0.0001	−.13	−.23	−.03	0.0085
Kallikrein-6 (KLK6)	.18	.08	.27	0.0003	.15	.03	.26	0.012
Heparin-binding EGF-like growth factor (HB-EGF)	.18	.08	.28	0.00029	.12	.01	.24	0.037
Growth/differentiation factor 15 (GDF-15)	−.19	−.29	−.09	0.00013	−.11	−.23	.00	0.049
Tissue-type plasminogen activator (t-PA)	−.33	−.42	−.24	<0.0001	−.10	−.19	.00	0.054
Cathepsin D (CTSD)	−.26	−.35	−.17	<0.0001	−.04	−.14	.06	0.46
Hepatocyte growth factor (HGF)	−.25	−.35	−.16	<0.0001	−.02	−.13	.08	0.67
E-selectin (SELE)	−.23	−.33	−.14	<0.0001	−.07	−.18	.04	0.20
Stem cell factor (SCF)	.23	.13	.32	<0.0001	.10	−.01	.22	0.073
Vascular endothelial growth factor D (VEGF-D)	.18	.09	.27	<0.0001	.06	−.04	.16	0.26
Follistatin (FS)	−.19	−.29	−.09	0.00012	−.07	−.18	.05	0.25
Fibroblast growth factor 23 (FGF-23)	−.17	−.27	−.08	0.0004	−.10	−.21	.01	0.084
Tumor necrosis factor ligand superfamily member 14 (TNFSF14)	−.17	−.27	−.07	0.00057	.04	−.07	.15	0.47

^†Multivariable linear regression further adjusted for fat mass (DXA), fasting glucose (mmol/L), LDL (mmol/L), WHR, smoking status, blood pressure (mmHg), educational level, and lpnr (lab test sequence number)