Skip to main content

Table 2 The associations between VO2peak normalized for lean mass, and the circulating proteins: sex- and multivariable adjusted linear regression. Only proteins that met the Bonferroni adjusted threshold (p<0.0006) in the primary sex adjusted analyses are presented. Proteins that met p<0.05 threshold in the multivariable-adjusted analyses are highlighted in bold

From: Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study

Protein Sex-adjusted Multivariable-adjusted
beta 95% CI 95% CI p-value beta 95% CI 95% CI p-value
  low high    low high  
Fatty acid-binding protein 4 (FABP4) −.41 −.49 −.32 <0.0001 −.17 −.25 −.09 <0.0001
Interleukin-6 (IL-6) −.34 −.43 −.25 <0.0001 −.21 −.31 −.10 0.00015
Leptin −.36 −.43 −.29 <0.0001 −.09 −.15 −.04 0.001
Galanin .25 .16 .35 <0.0001 .18 .07 .29 0.002
Cystatin-B (CSTB) −.31 −.40 −.21 <0.0001 −.16 −.27 −.05 0.0046
Interleukin-1 receptor antagonist protein (IL-1RA) −.39 −.48 −.30 <0.0001 −.13 −.23 −.03 0.0085
Kallikrein-6 (KLK6) .18 .08 .27 0.0003 .15 .03 .26 0.012
Heparin-binding EGF-like growth factor (HB-EGF) .18 .08 .28 0.00029 .12 .01 .24 0.037
Growth/differentiation factor 15 (GDF-15) −.19 −.29 −.09 0.00013 −.11 −.23 .00 0.049
Tissue-type plasminogen activator (t-PA) −.33 −.42 −.24 <0.0001 −.10 −.19 .00 0.054
Cathepsin D (CTSD) −.26 −.35 −.17 <0.0001 −.04 −.14 .06 0.46
Hepatocyte growth factor (HGF) −.25 −.35 −.16 <0.0001 −.02 −.13 .08 0.67
E-selectin (SELE) −.23 −.33 −.14 <0.0001 −.07 −.18 .04 0.20
Stem cell factor (SCF) .23 .13 .32 <0.0001 .10 −.01 .22 0.073
Vascular endothelial growth factor D (VEGF-D) .18 .09 .27 <0.0001 .06 −.04 .16 0.26
Follistatin (FS) −.19 −.29 −.09 0.00012 −.07 −.18 .05 0.25
Fibroblast growth factor 23 (FGF-23) −.17 −.27 −.08 0.0004 −.10 −.21 .01 0.084
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) −.17 −.27 −.07 0.00057 .04 −.07 .15 0.47
  1. Multivariable linear regression further adjusted for fat mass (DXA), fasting glucose (mmol/L), LDL (mmol/L), WHR, smoking status, blood pressure (mmHg), educational level, and lpnr (lab test sequence number)