Skip to main content

Table 3 Summary of the responses to training on inflammation markers in adolescent athletes with an overview of the variables examined, the type of activity and sampling times, and the main findings in relation to each variable.

From: Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis

Author and date, sport Participants Redox status variables examined Type of activity and sampling times Main findings
Brunelli et al. 2014 [55] basketball 11 male adolescent athletes, age 13.3 ± 0.6 years IL-6, IL-10, C-RP, TNF-α Four blood samples were collected at pre-season, preparatory, and competitive time points Competitive period compared to preseason: ↑TNF-α, C-RP, ↓IL-10. Competitive period compared to preparatory period: ↑IL-6
Eliakim et al. 2009 [28], volleyball 14 adolescent males, age 16.3 ± 1.1 years, and 13 females, age 16.0 ± 0.4 years GH, IGF-I, T, C, IL-6, IL-1ra The effect of a typical volleyball practice. Blood samples collected pre- and post-training In both genders, after test: ↔IL-1ra, ↑IL-6
Eliakim et al. 2013 [29] volleyball 13 female, national team level players, age 16.0 ± 1.4 years GH, IGF-I, IGFB3, C, IL-6, IL-1ra Samples obtained pre-, post-, 1 h post a volley training at preseason and after 7 weeks of preparation In both conditions, athletes had: ↑IL-6, ↔IL-1ra
Jurimae at al. 2018 [56], rowing 15 female rowers, age 18.3 ± 1.6 years IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, IL-1α, IL-1β, VEGF, MCP-1 Blood samples pre- and 1 h post-endurance exercise ↑IL-6, IL-8, VEGF, MCP-1
Meckel et al. 2009 [37], handball 12 junior handball players, age range 17–20 years GH, IGF, IL-6, IL-1b, IL-1ra, IL-10 Sprint run on a treadmill, at an intensity of 80%. Samples collected at pre-, after each 250-m run, and 60 min post-last 250 m After exercise athletes displayed: ↑IL-6, ↔ IL-1b, IL-1ra, IL-10
Nemet et al. 2002 [38], wrestling 11 high school boys, aged range 14–18.5 years IL-6, TNF-α, IGF-1, IGFBP1, IGFBP3, IL-1ra, IL-1b A single, typical, 1.5 h wrestling practices session. Samples collected pre- and post-training After typical training wrestlers had: ↑TNF-α, IL-1ra, IL-1b, IL-6
Nemet et al. 2003 [39], water polo 10 elite female water polo players, age 15.1 ± 0.3 years IL-6, TNF-α, IL-1ra, IL-1b Pre- and post a typical, 1.5 h water polo practice session After a water polo session, athlete had: ↑IL-6, IL-1ra, ↔ IL-1b, TNF-α
Nemet et al. 2004 [40], wrestling 11 elite male wrestlers, age 16.5 ± 0.5 years IL-6, TNF-α, IL-1ra, IL-1b During a school year, athletes were monitored at pre, mid-, peak-, post- training season. Athletes displayed at: Mid-season: ↑IL-1ra, IL-6. Post-season: ↓IL-1ra, IL-6. All year: ↔IL-1b, TNF-α
Nemet et al. 2009 [41], cross-country 8 elite female cross-country runners, age 16.8 ± 0.5 years IL-6, IL-1ra Pre- and post a typical one-hour endurance training. Blood samples obtained pre- and post-training. Post training athletes had|: ↑IL-6, IL-1ra, TNF-α, IL-1b
Ziemann et al. 2013 [57], tennis 15 adolescent athletes, age 16 years H2O2, IL-1b, TNF-α, IL-6, IL-10, Hsp27, Hsp70, CK Blood was collected 3 times during a tennis camp: after arrival, after 3 days of active rest and at the end of the camp (14 days). Post tournament: ↑H2O2, IL-1b, TNF-α, HSP70. After the conditioning camp: ↓H2O2,, IL-1b, TNF-α, HSP70, CK, ↑IL-6, IL-10, HSP27
  1. IL-6 Interleukin-6, IL-10 interleukin-10, IL-1ra interleukin-1 receptor antagonist, IL-1b interleukin, IL-2 interleukin, IL-4 interleukin, IL-8 interleukin, C-RP C-reactive protein, TNF-α tumour necrosis factor-α, T testosterone, C cortisol, GH growth hormone, IGF-1 insulin-like growth, IGFB3 insulin-like growth binding protein-3, VEGF vascular endothelial growth factor, MCP-1 monocyte chemoattractant protein-1, Hsp 27 heat shock protein-27, Hsp70 heat shock protein-70, H2O2 hydrogen peroxide, CK creatine kinase