Fig. 7

Numbers of newborn neurons in the hippocampus and BDNF/TrkB expression in hippocampus and entorhinal cortex of SynIIKO mice after 1 month of voluntary running before seizure onset. Distribution of DCX⁺ cells within the subgranular zone (SGZ) of the dentate gyrus in the hippocampus in exercised mice as compared to sedentary SynIIKO mice (group D) (a, b). Number of DCX⁺ cells as mean number of cells/brain section (c). BDNF expression in the dentate hilus, GCL and ML of the hippocampus in sedentary and exercised SynIIKO mice (d, e), with representative region of interest delineated also in tubulin III (f). TrkB expression in the entorhinal cortex in sedentary and exercised SynIIKO mice (g, h), with representative region of interest indicated also in NeuN staining (i). *p < 0.05, unpaired Student’s t test, n_sedentary = 12 and n_exercised = 12