Fig. 5

Delayed seizure onset in synapsin II knockout (SynIIKO) mice following voluntary running. Percentage of SynIIKO mice with or without voluntary running (exercised and sedentary group) exhibiting provoked seizures (a, c, e) and cumulative seizure load during the provocation period (b, d, f). Group A starting 1.5 months before the 8-week long provocation period (a, b). Group B voluntary running for 2 months starting concurrently with seizure provocations (c, d). Group C voluntary running for in total 1 month starting 1 month before provocation period (e, f). Corticosterone level in both the sedentary and exercised group was reduced at 2 months compared to 1 month of age. However, no differences were observed in corticosterone levels in faeces before (T_{0; mice 1 month of age}) and after (T_{1; mice 2 months of age}) 1 month of voluntary running between sedentary and exercised mice (g). *p < 0.05, a–c Fisher exact test and group D paired Student’s t test. Group A n_sedentary = 12 and n_exercised = 11, group B n_sedentary = 12 and n_exercised = 13, group C n_sedentary = 10 and n_exercised = 13, group D n_sedentary = 12 and n_exercised = 12