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Table 2 Summary effects in the overall, modifier (HWE), and subgroup (tendon/ligament) analyses of COL5A1 with TLI

From: Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Comparison [R] genetic model n Test of association Test of heterogeneity
OR 95% CI P a P b I2 (%) AM
rs12722 All [26,27,28,29,30,31,32]
 H 9 0.69 0.54–0.89 0.003 0.25 21 FE
 R 9 0.72 0.52–0.99 0.04 0.05 48 RE
 D 9 0.90 0.68–1.21 0.49 0.001 69 RE
 C 9 0.87 0.69–1.10 0.24 0.0001 75 RE
rs13946 All [26, 30,31,32]
 H 5 0.83 0.33–2.08 0.69 0.006 72 RE
 R 5 0.79 0.35–1.78 0.57 0.02 67 RE
 D 5 1.12 0.78–1.63 0.54 0.02 65 RE
 C 5 1.01 0.76–1.34 0.94 0.03 63 RE
rs12722 HWE [27,28,29,30,31,32]
 H 7 0.68 0.52–0.88 0.004 0.13 39 FE
 R 7 0.76 0.53–1.09 0.13 0.04 55 RE
 D 7 0.86 0.66–1.12 0.27 0.05 52 RE
 C 7 0.88 0.66–1.17 0.37 10−5 79 RE
rs13946 HWE [26, 30,31,32]
 H 4 1.03 0.39–2.72 0.95 0.02 70 RE
 R 4 1.00 0.44–2.27 1.00 0.05 61 RE
 D 4 1.15 0.72–1.83 0.56 0.01 73 RE
 C 4 1.06 0.76–1.46 0.74 0.03 68 RE
rs12722 Tendon [26,27,28, 31]
 H 5 0.87 0.59–1.27 0.46 0.11 47 FE
 R 5 0.81 0.42–1.57 0.53 0.009 70 RE
 D 5 0.84 0.55–1.29 0.43 0.01 73 RE
 C 5 0.98 0.62–1.55 0.95 10−5 86 RE
rs13946 Tendon [26, 31]
 H 3 0.70 0.14–3.56 0.66 0.001 85 RE
 R 3 0.63 0.16–2.58 0.52 0.005 81 RE
 D 3 1.15 0.63–2.12 0.65 0.01 78 RE
 C 3 0.97 0.58–1.61 0.90 0.006 81 RE
rs12722 Ligament [29, 30, 32]
 H 4 0.59 0.43–0.82 0.001 0.96 0 FE
 R 4 0.65 0.49–0.86 0.003 0.80 0 FE
 D 4 0.99 0.66–1.50 0.96 0.03 68 RE
 C 4 0.77 0.66–0.90 0.0009 0.95 0 FE
rs13946 Ligament [30, 32]
 H 2 1.07 0.51–2.26 0.85 0.39 0 FE
 R 2 1.10 0.54–2.24 0.80 0.22 34 FE
 D 2 1.04 0.74–1.46 0.82 0.16 48 FE
 C 2 1.04 0.80–1.35 0.79 0.53 0 FE
  1. Cut-offs for Pa and Pb are < 0.05 and 0.10, respectively. Values in italics indicate significant associations
  2. H homozygous, R recessive, D dominant, C codominant, n number of studies, [R] references, OR odds ratio, CI confidence interval, Pa p value for association, Pb p value for heterogeneity, AM analysis model, HWE Hardy–Weinberg Equilibrium, FE fixed-effects, RE random-effects