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Sports Medicine - Open

Table 2 Summary effects in the overall, modifier (HWE), and subgroup (tendon/ligament) analyses of COL5A1 with TLI

From: Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Comparison [R] genetic model

n

Test of association

Test of heterogeneity

OR

95% CI

P a

P b

I2 (%)

AM

rs12722 All [26,27,28,29,30,31,32]

 H

9

0.69

0.54–0.89

0.003

0.25

21

FE

 R

9

0.72

0.52–0.99

0.04

0.05

48

RE

 D

9

0.90

0.68–1.21

0.49

0.001

69

RE

 C

9

0.87

0.69–1.10

0.24

0.0001

75

RE

rs13946 All [26, 30,31,32]

 H

5

0.83

0.33–2.08

0.69

0.006

72

RE

 R

5

0.79

0.35–1.78

0.57

0.02

67

RE

 D

5

1.12

0.78–1.63

0.54

0.02

65

RE

 C

5

1.01

0.76–1.34

0.94

0.03

63

RE

rs12722 HWE [27,28,29,30,31,32]

 H

7

0.68

0.52–0.88

0.004

0.13

39

FE

 R

7

0.76

0.53–1.09

0.13

0.04

55

RE

 D

7

0.86

0.66–1.12

0.27

0.05

52

RE

 C

7

0.88

0.66–1.17

0.37

10−5

79

RE

rs13946 HWE [26, 30,31,32]

 H

4

1.03

0.39–2.72

0.95

0.02

70

RE

 R

4

1.00

0.44–2.27

1.00

0.05

61

RE

 D

4

1.15

0.72–1.83

0.56

0.01

73

RE

 C

4

1.06

0.76–1.46

0.74

0.03

68

RE

rs12722 Tendon [26,27,28, 31]

 H

5

0.87

0.59–1.27

0.46

0.11

47

FE

 R

5

0.81

0.42–1.57

0.53

0.009

70

RE

 D

5

0.84

0.55–1.29

0.43

0.01

73

RE

 C

5

0.98

0.62–1.55

0.95

10−5

86

RE

rs13946 Tendon [26, 31]

 H

3

0.70

0.14–3.56

0.66

0.001

85

RE

 R

3

0.63

0.16–2.58

0.52

0.005

81

RE

 D

3

1.15

0.63–2.12

0.65

0.01

78

RE

 C

3

0.97

0.58–1.61

0.90

0.006

81

RE

rs12722 Ligament [29, 30, 32]

 H

4

0.59

0.43–0.82

0.001

0.96

0

FE

 R

4

0.65

0.49–0.86

0.003

0.80

0

FE

 D

4

0.99

0.66–1.50

0.96

0.03

68

RE

 C

4

0.77

0.66–0.90

0.0009

0.95

0

FE

rs13946 Ligament [30, 32]

 H

2

1.07

0.51–2.26

0.85

0.39

0

FE

 R

2

1.10

0.54–2.24

0.80

0.22

34

FE

 D

2

1.04

0.74–1.46

0.82

0.16

48

FE

 C

2

1.04

0.80–1.35

0.79

0.53

0

FE

  1. Cut-offs for Pa and Pb are < 0.05 and 0.10, respectively. Values in italics indicate significant associations
  2. H homozygous, R recessive, D dominant, C codominant, n number of studies, [R] references, OR odds ratio, CI confidence interval, Pa p value for association, Pb p value for heterogeneity, AM analysis model, HWE Hardy–Weinberg Equilibrium, FE fixed-effects, RE random-effects
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