Association of COL5A1 gene polymorphisms and risk of tendon-ligament injuries among Caucasians: a meta-analysis

Sports Medicine - Open

Table 1 Characteristics of the included studies that examined the association of COL5A1 polymorphisms with TLI studies

K	First author	[R]	n	Year	Country	TLI	COL5A1 Polymorphisms	Tissue Sources	UM	BM	CB Score
1	Abraham	[25]	2	2013	SA/AU	AT	rs71746744/rs16399	Blood	Yes	Ag/He	8
2	Altinisik	[26]	1	2015	TUR	TE	rs12722, rs13946	Blood	Yes	Ag/Sx	7
3	Brown	[27]	1	2016	UK	ATP	rs12722/rs3196378/rs71746744	Oral	Yes	Ag/G	8
4	Mokone	[28]	1	2006	SA	ATP	rs12722	Blood	Yes	Ag/Sx	8
5	O’Connell	[29]	2	2014	SA/POL	ACLR	rs12722	Blood	Yes	Ag/Sx/We	9
6	Posthumus	[30]	1	2009	SA	ACLR	rs12722/rs13946	Blood	Yes	Ag	6
7	September	[31]	2	2009	SA/AU	AT	rs12722/rs13946/rs3196378	Blood	Yes	Ag/G	8
8	Stepien–Slodkowska	[32]	1	2015	POL	ACLR	rs12722/rs13946	Oral	Yes	NM	9

K number designation of the article, [R] reference, n number of studies per article, SA South Africa, AU Australia, TUR Turkey, UK United Kingdom, POL Poland, TLI tendon-ligament injury, AT achilles tendinopathy, TE tennis elbow, ATP achilles tendon pathology, ACLR anterior cruciate ligament rupture, rs12722 BstUI, rs13946 DpnII, UM used matching, BM basis for matching, Ag age, He height, Sx sex, G geography, We weight, NM no mention, CB Clark–Baudouin