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Table 3 Included randomized controlled trials

From: Exercise in Pregnancy and Children’s Cardiometabolic Risk Factors: a Systematic Review and Meta-Analysis

First author and year

Country

Population characteristics

Timing of intervention

Intervention type

Frequency

Intensity

Supervised

Sample size neonates (E/C)

Neonate outcome

Weight

FM

LGA

Erkkola 1975 [54]

Finland

Healthy

10–14 GW To 38 GW

Aerobic

3×/wk 60 min

Moderate to Vigorous ~140 bpm HR and fatigue

NR

44 (23/21)

  

Hollings- worth 1987 [61]

USA

Type 1 diabetes

13 GW to 37–40 GW

Aerobic

Daily 20 min after each meal

NR

No

33 (13/21)

  

Avery 1997 [47]

USA

GDM sedentary (exercise <2×/wk)

28 GW to delivery

Aerobic walking and cycling

3-4×/wk 30 min

Moderate < 70% HR max

Partial

29 (15/14)

  

Kihlstrand 1999 [78]

Sweden

Healthy

20 GW to delivery

Aerobic

1×/wk, 30 min

NR

Yes

241 (122/119)

  

Clapp 2000 [49]

USA

Healthy

Did not regularly exercise (not defined)

8 GW to delivery

Aerobic

3-5×/wk 20 min

Moderate 55–60% VO2 max

Yes

46 (22/24)

 

Marquez-Sterling 2000 [66]

USA

No regular exercise in the last year

18–20 GW to delivery

Aerobic

3×/wk 60 min

Moderate to vigorous 120–156 bpm

Yes

15 (9/6)

  

Garshabi 2005 [56]

Iran

Healthy

No history of exercise

17–22 GW to 29–34 GW

Aerobic and resistance

3×/wk 60 min

Moderate < 140 bpm

Yes

212 (107/105)

  

Santos 2005 [81]

Brazil

Healthy

25 kg/m2 < BMI <  30 kg/m2

18 GW to NR

Aerobic and resistance

3×/wk 40–45 min

Moderate 50–60% HR max < 140 bpm

Yes

72 (37/35)

  

Baciuk 2008 [43]

Brazil

No regular exercise

18–20 GW to delivery

Aerobic

3×/wk 50 min

Moderate < 70% HR max

Yes

70 (33/37)

  

Barakat 2009 [44]

Spain

Healthy

Sedentary (exercise < 20 min, 3×/wk)

12–13 GW to 38–39 GW

Resistance

3×/wk. 35–40 min

Light to vigorous < 60–< 80% HR max 10–12 Rep range

Yes

142 (72/70)

  

De Barros 2010 [52]

Brazil

GDM

Sedentary (IPAQ)

31 GW to delivery

Resistance

3×/wk 30–40 min

Moderate to vigorous 5–6 RPE/10

Partial

64 (32/32)

  

Hopkins 2010 [62]

New Zealand

Healthy

2 GW to 36 GW or delivery

Aerobic

≤ 5 days 40 min

Moderate to vigorous 65% VO2 max

Partial

84 (47/37)

Haakstad 2011 [59]

Norway

Healthy

No structured exercise (> 60 min 1×/wk)

17–18 GW 36–38 GW

Aerobic and resistance

2-7×/wk 60 min

Moderate to vigorous 12–14 RPE

Partial

105 (52/53)

  

Nascimento 2011 [68]

Brazil

BMI ≥ 26 kg/m2

17 GW to delivery

Aerobic and resistance

6×/wk 40 min

Moderate < 140 bpm

Partial

82

(40/42)

 

De Oliveria Melo 2012 [53]

Brazil

Inactive

Healthy

13 or 20 GW to delivery

Aerobic

3×/wk > 15 min

Moderate to vigorous 60–80% HR max Borg RPE 12–16

Yes

171 (54/60/57)

 

Oostdam 2012 [69]

Netherlands

BMI ≥ 25 kg/m2 with additional risk factor for GDM

15 GW to delivery

Aerobic and resistance

2×/wk 60 min

Moderate to vigorous 12–14 RPE

Yes

105 (52/53)

 

Pinzon 2012 [72]

Colombia

Healthy

16–20 GW to 32–36 GW

Resistance

3×/wk 60 min

Light to moderate 55–75% HR max

Yes

35 (18/17)

  

Price 2012 [73]

USA

BMI < 39 kg/m2 No exercise (≥  1x/wk for 6 months)

12–14 GW to 36 GW

Aerobic and resistance

4×/wk 45–60 min

Moderate to vigorous 12–14 RPE

Partial

62 (31/31)

  

Barakat 2013 [46]

Spain

Healthy (exercise < 4×/wk)

6–9 GW to 38–39 GW

Aerobic, resistance

3×/wk 40–45 min

Light to moderate 60–75% HR max 10–12 Rep range

Yes

290 (138/152)

  

Kasawara 2013 [63]

Brazil

Chronic HTN or history of preeclampsia

12–20 GW to delivery

Aerobic

1×/wk 30 min

Light to moderate 20% above resting HR to < 140 bpm

Yes

103 (53/50)

  

Ruiz 2013 [79]

Spain

Exercise < 20 min < 3×/wk

9 GW to 38–39 GW

Aerobic and resistance

3×/wk, 25–30 min

Light to moderate < 60% HRmax Borg RPE 10–12

Yes

962 (481/481)

  

Barakat 2014 [48]

Spain

Healthy

9–13 GW to 39–40 GW

Aerobic, resistance

3×/wk 55–60 min

Moderate 55–60% HR max Borg RPE 12–13

Yes

200 (107/93)

  

Cordero 2014 [50]

Spain

Healthy

10–14 GW to delivery

Aerobic and resistance

3×/wk, 32 min

Moderate to vigorous < 60% HR max Borg RPE 12–14

Yes

257 (101/156)

  

Ghodsi 2014 [57]

Iran

BMI 19.8–26 kg/m2

No regular exercise

20–26 GW to 38 GW

Aerobic

3×/wk 15 min

Light to moderate 50–60% HR max

No

80 (40/40)

  

Kong 2014 [64]

USA

BMI ≥ 25 kg/m2 (<  30 min, 3×/wk)

12–15 GW To 35 GW

Aerobic

5×/wk. 30 min

Moderate (step counts)

No

37 (18/19)

  

Murtezani 2014 [67]

Kosovo

Healthy (exercise < 20 min, 3×/wk)

14–20 GW to delivery

Aerobic and resistance

3×/wk 40–45 min

Moderate to vigorous 12–14 RPE

Yes

63 (30/33)

  

Petrov Fieril 2014 [71]

Sweden

Healthy

14 GW to 25 GW

Resistance

2×/wk 60 min

Moderate to vigorous (self-selected)

No

72 (38/34)

  

Hellenes 2015 [60]

Norway

Healthy

18–22 GW to 32–36 GW

Aerobic and resistance

3×/wk 45–60 min

Moderate to vigorous 13–14 RPE

Partial

855 (429/426)

  

Ramos 2015 [74]

Brazil

GDM

24–28 GW to 38 GW

Aerobic

3×/wk 50 min

NR

NR

6 (2/4)

  

Ussher 2015 [76]

United Kingdom

Smokers (> 4 cigarettes/day prior to pregnancy)

10–24 GW for 8 GW

Aerobic

1-2×/wk 30 min

Moderate (self-report)

Yes

713 (354/359)

  

Barakat 2016 [45]

Spain

Healthy

9–11 GW to 38–39 GW

Aerobic, resistance

3×/wk 50–55 min

Moderate to vigorous < 70% HR max Borg RPE 12–14

Yes

765 (382/383)

  

Guelfi 2016 [58]

Australia

History of GDM in previous pregnancies with no structured exercise

14 to 28 GW

Aerobic

3×/wk 30-60 min

Moderate to vigorous intervals 65–85% HR max

Yes

172 (87/85)

 

Perales 2016 [70]

Spain

Pre gestational exercise < 4×/ wk. or current exercise ≤ 2×/wk 20 mins

9–11 GW To delivery

Aerobic, Resistance

3×/wk 55-60 min

Light to moderate 55–60% HR max

Yes

166 (83/83)

  

Seneviratne 2016 [75]

New Zealand

BMI ≥ 25 kg/m2

20 GW to 35 GW

Aerobic

3 5×/wk 15–30 min

Moderate 40–59% VO2R

No

74 (37/37)

 

Daly 2017 [51]

Ireland

No diabetes

BMI > 30 kg/m2

12 GW to 6 wk. post-partum

Aerobic and resistance

3×/wk 30–40 min

NR

Yes

87 (44/43)

  

Labonte 2017 [65]

Canada

Healthy

BMI 18.5–25 kg/m2

2nd to 3rd trimester

Aerobic

3×/wk 20 min

Moderate 55% VO2max

Partial

18 (19/8)

  

Garnaes 2017 [55]

Norway

BMI > 28 kg/m2 (exercise < 2×/week)

12–18 GW to delivery

Aerobic and resistance

3–5/wk 60 min

Moderate to vigorous 12–15 RPE

Partial

74 (38/36)

  

Sklempe 2017 [80]

Croatia

GDM

22–26 GW to delivery

Aerobic and resistance

2–7×/wk 40–45 min

Moderate 65–75% HR max Borg RPE 13–14

Partial

38 (18/20)

  

Wang 2017 [77]

China

BMI > 24 kg/m2

8–12 GW to delivery

Aerobic

3×/wk 30–60 min

Light to vigorous intervals 50–85% HR max

Yes

226 (112/114)

 

  1. Outcomes columns with dot indicate the specific outcome was reported by the study. BMI body mass index, Bpm beat per minute, FM fat mass, GDM gestational diabetes mellitus, GW gestational weeks, HR heart rate, LGA large-for-gestational age, NR not reported, RPE rating of perceived exertion, VO2max maximal oxygen consumption, VO2R oxygen uptake reserve, wk week