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Table 3 Median (95% CI) ACTH response to insulin tolerance test (ITT)

From: Hypothalamic-Pituitary-Adrenal (HPA) Axis Functioning in Overtraining Syndrome: Findings from Endocrine and Metabolic Responses on Overtraining Syndrome (EROS)—EROS-HPA Axis

ACTH response to ITT (pg/mL) OTS athletes (OTS) (n = 14) Healthy athletes (ATL) (n = 25) Non-active subjects (NCS) (n = 12) p
Basal 19.6 (11.4–32.9) 18.7 (6.5–37.8) 21.4 (8.7–37.8) n/s
During hypoglycemia 28.2 (8.4–238.9) 57.8 (7.3–229.5) 29.5 (14.8–191.7) n/s
30′ after hypoglycemia 30.3**** (9.8–93.7) 59.9 (22.1–195.7) 51.4 (22.7–137.5) 0.006
Absolute increase 9.7**** (−14.4–64.4) 45.1 (22.1–195.7) 38.0 (0.5–108.8) 0.004
Percentage increase (%) 52.2 266.2 200.4 – n/a
  1. Differences between OTS and ATL: ****p < 0.001
  2. Level of significance = p < 0.05
  3. CI confidence interval; n/s = non significant; n/a = non appliable