Skip to main content

Table 3 Median (95% CI) ACTH response to insulin tolerance test (ITT)

From: Hypothalamic-Pituitary-Adrenal (HPA) Axis Functioning in Overtraining Syndrome: Findings from Endocrine and Metabolic Responses on Overtraining Syndrome (EROS)—EROS-HPA Axis

ACTH response to ITT (pg/mL)

OTS athletes (OTS) (n = 14)

Healthy athletes (ATL) (n = 25)

Non-active subjects (NCS) (n = 12)

p

Basal

19.6 (11.4–32.9)

18.7 (6.5–37.8)

21.4 (8.7–37.8)

n/s

During hypoglycemia

28.2 (8.4–238.9)

57.8 (7.3–229.5)

29.5 (14.8–191.7)

n/s

30′ after hypoglycemia

30.3**** (9.8–93.7)

59.9 (22.1–195.7)

51.4 (22.7–137.5)

0.006

Absolute increase

9.7**** (−14.4–64.4)

45.1 (22.1–195.7)

38.0 (0.5–108.8)

0.004

Percentage increase (%)

52.2

266.2

200.4

– n/a

  1. Differences between OTS and ATL: ****p < 0.001
  2. Level of significance = p < 0.05
  3. CI confidence interval; n/s = non significant; n/a = non appliable