Table 4 Modulation of TLR2 and TLR4 after chronic resistance exercise
Authors | Sample | Disease | Frequency, intensity, and duration | Post-exercise results | ||
|---|---|---|---|---|---|---|
TLR | Cytokine | Other | ||||
Zanchi et al. 2010 [120] | Wistar rats | No disease | 2 days/week, 80–95% MVSC, 12 weeks | ↓TLR4 | ↓TNF-α ↔IL-6 ↔IL-10 ↑IL-10/TNF-α ratio ↔IL-15 | ↔Hsp70 |
Cheng et al. 2015 [116] | Adults | Low back pain | 3 days/week, no information, 4 weeks | ↓TLR4 | ↓TNF-α ↓IL-6 ↓IFN-γ ↓IL-1β ↓IL-8 | ↓NF-kBp65, ↓p53, ↑SIRT1, ↑PGC-1α, ↑PPAR-γ, ↑FoxO1, ↑FoxO3, ↑IKB, ↑SOD |
Rodriguez-Miguelez et al. 2014 [119] | Elderly | No disease | 2 days/week, 60–80% 1 RM, 8 weeks | ↓TLR2, ↓TLR4 | ↔TNF-α ↑IL-10 | ↓MyD88, ↓p65, ↓phospho-p38/p38, ↓IKKi/IKKƐ, ↓TRIF, ↓phospho-IRF3/IRF3, ↓phospho-IRF7/IRF7, ↓Hsp60, ↑Hsp70, ↑phospho-ERK1/2, ↓CRP. |
Rodriguez-Miguelez et al. 2015 [92] | Elderly | No disease | 2 days/week, 20–35 Hz, 8 week | ↓TLR2, ↓TLR4 | ↓TNF-α ↑IL-10 | ↓MyD88, ↓p65, ↓TRIF, ↓Hsp60, ↑Hsp70, ↓CRP |
Prestes et al. 2015 [121] | Elderly | No disease | 2 days/week, 6–14 RM, 16 weeks | ↔TLR4 | ↔IL-1β ↔IL-10 ↔IL-1ra ↔ IL-15 | ↔BDNF, ↔irisin ↑functional capacity, ↑neuromuscular function, ↔body composition |
Phillips et al. 2012 [8] | Elderly | Obesity | 3 days/week, 8–12 RM, 12 weeks | ↔TLR4 | ↓TNF-α ↓IL-6 ↑IL10 | ↓CRP, ↓leptin, ↑LPS-IL10, ↑LPS-TNF, ↔body composition |