Polygenic study of endurance-associated genetic markers ACE I/D, ACTN3 Arg(R)577Ter(X), CKMM A/G NcoI and eNOS Glu(G)298Asp(T) in male Gorkha soldiers

Sports Medicine - Open

Table 7 Probability of possessing “optimal” genetic profile by number of polymorphism in the male Gorkha (TB) and Indian lowlander (IA) soldiers

Polymorphisms influencing endurance performance	New gene included at each stage	Gorkha (Tibeto-Burman)			Indian lowlander
		Typical frequency (%) of “optimal” genotype	Probability of possessing ‘perfect’ profile		Typical frequency (%) of “optimal” genotype	Probability of possessing “perfect” profile
		Typical frequency (%) of “optimal” genotype	% chance	Approximate odds ratio	Typical frequency (%) of “optimal” genotype	% chance	Approximate odds ratio
1.	ACE	43	43.00	1:2	25^a	25.00	1:4
2.	ACTN3	15	6.45	1:15	26^a	6.50	1.15
3.	CKMM	65	4.19	1:23	45	2.99	1:35
4.	eNOS	80	3.35	1:30	65	1.88	1:78

Data obtained from a data set of 100,000 hypothetical male Gorkha (TB) and Indian lowlander (IA), each with a randomly generated genetic profile for all four polymorphisms based on the typical frequency of each genotype
TB Tibeto-Burman, IA Indo-Aryan
^aGenotypic frequencies taken from [10]