Polygenic study of endurance-associated genetic markers ACE I/D, ACTN3 Arg(R)577Ter(X), CKMM A/G NcoI and eNOS Glu(G)298Asp(T) in male Gorkha soldiers

Sports Medicine - Open

Table 6 Comparison of genotypic and allelic frequencies of studied polymorphisms in male soldiers belonging to Gorkha (TB), Gorkha (IA), HAN (TB) and Indian lowlander (IA)

			Gorkha (TB)	Gorkha (IA)	HAN (TB)	Indian lowlander (IA)	Gorkha (TB) vs Gorkha (IA)	Gorkha (TB) vs HAN (TB)	Gorkha (TB) vs Indian lowlander (IA) (TB)	Gorkha (IA) vs HAN lowlander (IA)	Gorkha (IA) vs Indian lowlander (IA)	HAN (TB) vs Indian
SNP	Variants		Frequency						Level of significance (p)*
rs1799752	ACE I/D	Genotype
		II	0.427	0.459^a	0.408^a	0.254^a
		ID	0.467	0.417^a	0.551^a	0.504^a	0.525	0.291	0.000	0.130	0.000	0.003
		DD	0.104	0.122^a	0.040^a	0.240^a
		Allele
		I	0.671	0.673^a	0.683^a	0.506^a	0.676	0.664	0.000	0.849	1.0E-6	0.001
		D	0.338	0.326^a	0.316^a	0.493^a
rs1815739 C/T	ACTN3 Arg(R)577Ter(X)	Genotype
		RR	0.366	0.287^a	0.189	0.180^a	0.094	0.010	0.000	0.116	0.160	0.197
		RX	0.478	0.490^a	0.648	0.555^a
		XX	0.155	0.222^a	0.162	0.263^a
		Allele
		R	0.605	0.520^a	0.513	0.458^a	0.03	0.037	1.0E-6	0.89	0.149	0.240
		X	0.394	0.479^a	0.486	0.541^a
rs8111989 T/C	CKMM A/G NcoI	Genotype
		AA	0.655	0.475	0.594	0.455	0.004	0.608	0.000	0.289	0.245	0.065
		AG	0.296	0.445	0.351	0.388
		GG	0.048	0.079	0.054	0.155
		Allele
		A	0.803	0.698	0.770	0.650	0.001	0.357	1.0E-5	0.133	0.317	0.017
		G	0.196	0.301	0.230	0.350
rs1799983 G/T	eNOS Glu298Asp	Genotype
		GG	0.799	0.653	0.682	0.648	0.000	0.223	0.000	0.674	0.094	0.861
		GT	0.184	0.287	0.292	0.333
		TT	0.016	0.588	0.024	0.018
		Allele
		G	0.891	0.797	0.829	0.814	4.9E-5	0.09	0.0002	0.51	0.554	0.754
		T	0.108	0.202	0.170	0.185

TB Tibeto-Burman, IA Indo-Aryan, HAN high-altitude native from Ladakh
*Significance for genotypic and allelic frequency is assumed when p < 0.05. The significant p values are italicized
^aData from [10]