A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults

Brown, William M. C.; Davison, Gareth W.; McClean, Conor M.; Murphy, Marie H.

doi:10.1186/s40798-015-0032-x

Sports Medicine - Open

Table 1 Summary of acute effects of exercise on inflammatory markers in healthy untrained individuals

From: A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults

Name (year)	Design	Subjects			Details of exercise trial	Sample times	Outcome	Reported change
Name (year)	Design	Group	n (gender)	Age (y)	Details of exercise trial	Sample times	Outcome	Reported change
Nieman et al. (1991) [50]	RCOT	Exercise	12 (F)	36.9 ± 2.2	Walking at 60 % VO₂max for 45 mins	Pre, P 0 and 1.5 h	NC	Increased from pre to P 0 h between groups
Nieman et al. (1991) [50]	RCOT	Control	12 (F)	36.9 ± 2.2	Walking at 60 % VO₂max for 45 mins	Pre, P 0 and 1.5 h	NC	Increased from pre to P 0 h between groups
Brenner et al. (1999) [7]	RCOT	Exercise	8 (M)	24.9 ± 2.3	Cycling at 90 % VO₂max for 5 mins	Pre, P 0, 3, 24 and 72 h	IL-6	No change within or between conditions
		Exercise	8 (M)	24.9 ± 2.3	Circuit (5 exercises; 3 sets × 10 reps) at 60–70 % 1RM	Pre, P 0, 3, 24 and 72 h	IL-6	No change within or between conditions
		Control
Lyngsø et al. (2002) [40]	RCT	Exercise	9 (8 M)	23.6 ± 0.4	Cycling at 60 % VO₂max for 1 h	Pre, P 0 and every 30 mins to 3 h	IL-6	Increased from Pre at P 0, 0.5, 1.5 and 2 h within the exercise condition
Lyngsø et al. (2002) [40]	RCT	Control	7 (5 M)	24.0 ± 0.3	Cycling at 60 % VO₂max for 1 h	Pre, P 0 and every 30 mins to 3 h	IL-6
Simonson and Jackson (2004) [66]	RCT	Exercise	8 (M)	30 ± 7	Resistance (8 exercises; 3 sets × 8–10 reps) at 75 % 1RM for 45 mins	Pre, P 0, 15 and 30 mins	NC	Increased from Pre to P 0, 15 and 30 mins within and between groups
Simonson and Jackson (2004) [66]	RCT	Control	8 (M)	30 ± 7		Pre, P 0, 15 and 30 mins	NC
Højbjerre et al. (2007) [28]	RCOT	Exercise	16 (M)	26.3 ± 0.8	Cycling at 55 % VO₂max for 1 h	Pre, P 0 and every 30 mins to 2.5 h	IL-6	Increased from Pre to P 0 and 2.5 h within the exercise group
Højbjerre et al. (2007) [28]	RCOT	Control	16 (M)	26.0 ± 0.7	Cycling at 55 % VO₂max for 1 h	Pre, P 0 and every 30 mins to 2.5 h	IL-6
Markovitch et al. (2008) [43]	RCOT	Exercise	12 (M)	54 ± 4	Walking at 50 % VO₂max for 30 mins	Pre, P 0, 2, 24, 48, 72 and 168 h	IL-6, CRP and NC	No change within or between conditions
Markovitch et al. (2008) [43]	RCOT	Control	12 (M)	54 ± 4	Walking at 50 % VO₂max for 30 mins	Pre, P 0, 2, 24, 48, 72 and 168 h	IL-6, CRP and NC	No change within or between conditions
Phillips et al. (2010) [58]	RCOT	Exercise 1	14 (M)	21.7 ± 1.7	Resistance exercise (2 sets of 12 reps at 65 % 1RM then 3rd set to fatigue)	Pre and P 0 h	IL-6	Increased from Pre to P 0 h with both intensities compared to control
		Exercise 2			Resistance exercise (2 sets of 8 reps at 85 % 1RM then 3rd set to fatigue)
		Control
Bizheh and Jaafari (2011) [4]	RCT	Exercise	14 (M)	44.9 ± 4.1	Circuit (10 exercises × 3 sets) at 35 % 1RM totaling 10 mins	Pre and P 0 h	CRP	Increased from Pre to P 0 h within the exercise group
Bizheh and Jaafari (2011) [4]	RCT	Control	9 (M)	43.1 ± 5.2		Pre and P 0 h	CRP	Increased from Pre to P 0 h within the exercise group
Davison (2011) [16]	RCOT	Exercise	9(M)	27 ± 5	Cycling Wingate Test (4 × 30 s)	Pre, P 0 and 30 mins	NC	Increased from Pre to P 0 and 30 mins within and between groups
Davison (2011) [16]	RCOT	Control	9(M)	27 ± 5	Cycling Wingate Test (4 × 30 s)	Pre, P 0 and 30 mins	NC
Almada et al. (2013) [2]	RCT	Exercise	5 (M)	20.6 ± 2.1	Running submaximally for 45 mins followed by 7 mins at 90 % VO₂max	Pre and P 0 h	IL-6	Increased from Pre to P 0 h within and between groups
Almada et al. (2013) [2]	RCT	Control	5 (M)	20.6 ± 2.1		Pre and P 0 h	IL-6	Increased from Pre to P 0 h within and between groups

RCOT randomised crossover trial, RCT randomised control trial, n number of participants, F female, M males, y years of age, mins minutes, 1 RM 1 repetition maximum, h hour(s), Pre pre-exercise, P post-exercise, NC neutrophil count, IL-6 interleukin-6, CRP C-reactive protein

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