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Table 1 Summary of acute effects of exercise on inflammatory markers in healthy untrained individuals

From: A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults

Name (year) Design Subjects Details of exercise trial Sample times Outcome Reported change
Group n (gender) Age (y)
Nieman et al. (1991) [50] RCOT Exercise 12 (F) 36.9 ± 2.2 Walking at 60 % VO2max for 45 mins Pre, P 0 and 1.5 h NC Increased from pre to P 0 h between groups
Control
Brenner et al. (1999) [7] RCOT Exercise 8 (M) 24.9 ± 2.3 Cycling at 90 % VO2max for 5 mins Pre, P 0, 3, 24 and 72 h IL-6 No change within or between conditions
Exercise Circuit (5 exercises; 3 sets × 10 reps) at 60–70 % 1RM
Control       
Lyngsø et al. (2002) [40] RCT Exercise 9 (8 M) 23.6 ± 0.4 Cycling at 60 % VO2max for 1 h Pre, P 0 and every 30 mins to 3 h IL-6 Increased from Pre at P 0, 0.5, 1.5 and 2 h within the exercise condition
Control 7 (5 M) 24.0 ± 0.3
Simonson and Jackson (2004) [66] RCT Exercise 8 (M) 30 ± 7 Resistance (8 exercises; 3 sets × 8–10 reps) at 75 % 1RM for 45 mins Pre, P 0, 15 and 30 mins NC Increased from Pre to P 0, 15 and 30 mins within and between groups
Control 8 (M)
Højbjerre et al. (2007) [28] RCOT Exercise 16 (M) 26.3 ± 0.8 Cycling at 55 % VO2max for 1 h Pre, P 0 and every 30 mins to 2.5 h IL-6 Increased from Pre to P 0 and 2.5 h within the exercise group
Control 26.0 ± 0.7
Markovitch et al. (2008) [43] RCOT Exercise 12 (M) 54 ± 4 Walking at 50 % VO2max for 30 mins Pre, P 0, 2, 24, 48, 72 and 168 h IL-6, CRP and NC No change within or between conditions
Control
Phillips et al. (2010) [58] RCOT Exercise 1 14 (M) 21.7 ± 1.7 Resistance exercise (2 sets of 12 reps at 65 % 1RM then 3rd set to fatigue) Pre and P 0 h IL-6 Increased from Pre to P 0 h with both intensities compared to control
Exercise 2 Resistance exercise (2 sets of 8 reps at 85 % 1RM then 3rd set to fatigue)
Control  
Bizheh and Jaafari (2011) [4] RCT Exercise 14 (M) 44.9 ± 4.1 Circuit (10 exercises × 3 sets) at 35 % 1RM totaling 10 mins Pre and P 0 h CRP Increased from Pre to P 0 h within the exercise group
Control 9 (M) 43.1 ± 5.2
Davison (2011) [16] RCOT Exercise 9(M) 27 ± 5 Cycling Wingate Test (4 × 30 s) Pre, P 0 and 30 mins NC Increased from Pre to P 0 and 30 mins within and between groups
Control
Almada et al. (2013) [2] RCT Exercise 5 (M) 20.6 ± 2.1 Running submaximally for 45 mins followed by 7 mins at 90 % VO2max Pre and P 0 h IL-6 Increased from Pre to P 0 h within and between groups
Control 5 (M)
  1. RCOT randomised crossover trial, RCT randomised control trial, n number of participants, F female, M males, y years of age, mins minutes, 1 RM 1 repetition maximum, h hour(s), Pre pre-exercise, P post-exercise, NC neutrophil count, IL-6 interleukin-6, CRP C-reactive protein